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. 2023 May 1;32(3):215-221.
doi: 10.1097/CEJ.0000000000000613. Epub 2020 Sep 10.

Adult height and risk of gastric cancer: a pooled analysis within the Stomach cancer Pooling Project

Luca Giraldi  1 , Jovana Stojanovic  1   2   3 , Dario Arzani  1 , Roberto Persiani  4   5 , Jinfu Hu  6 , Kenneth C Johnson  7 , Zuo-Feng Zhang  8 , Monica Ferraroni  9 , Domenico Palli  10 , Guo-Pei Yu  11 , Carlo La Vecchia  9 , Claudio Pelucchi  9 , Nuno Lunet  12   13 , Ana Ferro  13 , Reza Malekzadeh  14 , Joshua Muscat  15 , David Zaridze  16 , Dmitry Maximovich  16 , Nuria Aragones  17   18 , Vicente Martin  18   19 , Jesùs Vioque  18   20 , Eva M Navarrete-Munoz  18   20 , Mohammadreza Pakseresht  14   21   22 , Eva Negri  23 , Matteo Rota  9 , Farhad Pourfarzi  14   24 , Lina Mu  25 , Robert C Kurtz  26 , Areti Lagiou  27 , Pagona Lagiou  28   29 , Roberta Pastorino  1 , Stefania Boccia  1   5
Affiliations

Adult height and risk of gastric cancer: a pooled analysis within the Stomach cancer Pooling Project

Luca Giraldi et al. Eur J Cancer Prev. .

Abstract

Background: The association between height and risk of gastric cancer has been studied in several epidemiological studies with contrasting results. The aim of this study is to examine the association between adult height and gastric cancer within a large pooled analysis of case-control studies members of the Stomach cancer Pooling (StoP) Project consortium.

Methods: Data from 18 studies members of the StoP consortium were collected and analyzed. A multivariable logistic regression model was used to estimate the study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between 10-cm increase in height and risk of gastric cancer. Age, sex, tobacco smoking, alcohol consumption, social class, geographical area and Helicobacter pylori (H. pylori ) status were included in the regression model. Resulting estimates were then pooled with random-effect model. Analyses were conducted overall and in strata of selected variables.

Results: A total of 7562 cases and 19 033 controls were included in the analysis. The pooled OR was 0.96 (95% CI 0.87-1.05). A sensitivity analysis was performed restricting the results to the studies with information on H. pylori status, resulting in an OR of 0.97 (95% CI 0.79-1.20).

Conclusion: Our study does not support a strong and consistent association between adult height and gastric cancer.

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