Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021:254:163-181.
doi: 10.1007/398_2020_51.

Effects of Carbamazepine in Bivalves: A Review

Ângela Almeida  1 , Valdemar I Esteves  2 , Amadeu M V M Soares  1 , Rosa Freitas  3
Affiliations
Review

Effects of Carbamazepine in Bivalves: A Review

Ângela Almeida et al. Rev Environ Contam Toxicol. 2021.

Abstract

Carbamazepine (CBZ) is among the ten most frequent pharmaceuticals that occur in the aquatic systems, with known effects on inhabiting organisms, including bivalves. Bivalves are important species in coastal ecosystems, often exhibiting a dominant biomass within invertebrate communities. These organisms play a major role in the functioning of the ecosystem and particularly in food webs (as suspension-feeders) and represent a significant fraction of the fisheries resource. They also have strong interactions with the environment, water and sediment and are considered good bioindicator species. The present paper reviews the known literature on the impacts of CBZ in biological endpoints of marine bivalves exposed to environmentally and non-environmentally relevant concentrations, highlighting differences in terms of biological responses, associated with exposure period, concentrations tested, and species used. Overall, the literature available showed that CBZ induces individual and sub-individual effects in marine bivalves (adults and life stages) and the most common effect reported was the induction of oxidative stress.

Keywords: Antiepileptic; Bivalves; Marine environment; Pharmaceutical drugs; Sub-lethal effects.

PubMed Disclaimer

References

    1. Abdelhafidh K, Ali M, Hassen K, Badreddine S, Jaume A, Sandra P, Ethel E, Damià B, Hamouda B, Ezzeddine M (2018) Uptake and metabolism of carbamazepine (CBZ) by clam Ruditapes decussatus and its effects in biochemical responses. Xenobiotica 48:727–733
    1. Aguirre-Martínez GV, Buratti S, Fabbri E, DelValls AT, Martín-Díaz ML (2013) Using lysosomal membrane stability of haemocytes in Ruditapes philippinarum as a biomarker of cellular stress to assess contamination by caffeine, ibuprofen, carbamazepine and novobiocin. J Environ Sci 25:1408–1418
    1. Aguirre-Martínez GV, DelValls TA, Martín-Díaz ML (2016) General stress, detoxification pathways, neurotoxicity and genotoxicity evaluated in Ruditapes philippinarum exposed to human pharmaceuticals. Ecotoxicol Environ Saf 124:18–31
    1. Almeida Â, Calisto V, Esteves VI, Schneider RJ, Soares AM, Figueira E, Freitas R (2014) Presence of the pharmaceutical drug carbamazepine in coastal systems: effects on bivalves. Aquat Toxicol 156:74–87
    1. Almeida Â, Freitas R, Calisto V, Esteves VI, Schneider RJ, Soares AM, Figueira E (2015) Chronic toxicity of the antiepileptic carbamazepine on the clam Ruditapes philippinarum. Comp Biochem Physiol C Toxicol Pharmacol 172:26–35