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. 1977 Jun;74(6):2283-7.
doi: 10.1073/pnas.74.6.2283.

Inactivation and proteolytic cleavage of phage lambda repressor in vitro in an ATP-dependent reaction

J W Roberts, C W Roberts, D W Mount

Inactivation and proteolytic cleavage of phage lambda repressor in vitro in an ATP-dependent reaction

J W Roberts et al. Proc Natl Acad Sci U S A. 1977 Jun.

Abstract

We have reproduced in vitro the inactivation of bacteriophage lambda repressor that occurs in vivo when a lambda lysogen is treated with agents such as ultraviolet radiation that attack DNA. ATP and a divalent cation are required for the inactivation reaction. The ind- repressor is insensitive to the inactivation mechanism. A proteolytic cleavage of repressor accompanies inactivation in vitro, as it does in vivo.

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References

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