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Meta-Analysis
. 2020 Sep 14;22(1):215.
doi: 10.1186/s13075-020-02306-9.

Association between growth differentiation factor 5 rs143383 genetic polymorphism and the risk of knee osteoarthritis among Caucasian but not Asian: a meta-analysis

Lei Peng  1   2   3 , Song Jin  1 , Jiping Lu  3 , Chao Ouyang  3 , Jiang Guo  1   2 , Zhongyu Xie  1   2 , Huiyong Shen  4   5 , Peng Wang  6   7
Affiliations
Meta-Analysis

Association between growth differentiation factor 5 rs143383 genetic polymorphism and the risk of knee osteoarthritis among Caucasian but not Asian: a meta-analysis

Lei Peng et al. Arthritis Res Ther. .

Abstract

Background: A few months ago, the Bioscience Reports journal showed that growth differentiation factor 5 (GDF5) rs143383 genetic polymorphism increases the susceptibility of knee osteoarthritis (KOA), but previous studies' results have debates about available data. Considering the availability of more recent data, we focus on clarifying the relationship of KOA and GDF5 rs143383 genetic polymorphism by a meta-analysis of case-control trial data.

Methods: The eligible studies from the time of database established to Oct. 2019 were collected from PubMed, Springer, Cochrane library, Web of Science, China National Knowledge Infrastructure (CNKI), and Wan Fang library. Odds ratios (OR) and 95% confidence intervals (CI) were used to estimate the association between these polymorphisms and KOA risk. The meta-analysis was completed by STATA 18.0 software.

Results: A total of 196 studies were collected, 16 of them included in final meta-analysis (7997 cases and 12,684 controls). There was significant association between GDF5 rs143383 polymorphism and KOA in all genetic models (for Allele model (C versus T): OR = 0.84 (95% CI = 0.76-0.91); dominate model (CC+CT versus TT): OR = 0.80 (95% CI = 0.72-0.90); recessive model (CC versus CT+TT): OR = 0.79 (95% CI = 0.68-0.92); heterozygote model (CT versus CC+TT): OR = 0.89 (95% CI = 0.80-0.97); homozygous model (CC versus TT): OR = 0.71 (95% CI = 0.60-0.85)). In the subgroup analysis, we obtained the results that there is no significance among Asians.

Conclusion: GDF5 rs143383 genetic polymorphism increases the risk of KOA among Caucasians; CC genotype and C allele are protective factors for the susceptibility of KOA among Caucasians.

Keywords: Caucasian; Growth differentiation factor 5, rs143383; Knee osteoarthritis; Polymorphism.

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Conflict of interest statement

The authors declare that there are no competing interests associated with the article.

Figures

Fig. 1
Fig. 1
Studies identification diagram (from [13])
Fig. 2
Fig. 2
Forest of GDF5 genetic polymorphism (C>T) and KOA (CC vs CT+TT)
Fig. 3
Fig. 3
Forest of GDF5 genetic polymorphism (C>T) and KOA (C vs T)
Fig. 4
Fig. 4
Funnel plots of the association between GDF5 rs143383 polymorphism and knee osteoarthritis (a allele model, b dominate model, c recessive model, d homozygote model, e heterozygote model)
See this image and copyright information in PMC

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References

    1. Gregori D, et al. Association of pharmacological treatments with long-term pain control in patients with knee osteoarthritis: a systematic review and meta-analysis. JAMA. 2018;320(24):2564–2579. - PMC - PubMed
    1. Mokdad AH, et al. The state of US health, 1990-2016: burden of diseases, injuries, and risk factors among US states. JAMA. 2018;319(14):1444–1472. - PMC - PubMed
    1. Glyn-Jones S, et al. Osteoarthritis. Lancet. 2015;386(9991):376–387. - PubMed
    1. Peng L, et al. Lack of association between matrix metalloproteinase-1 gene rs1799750 polymorphism and osteoarthritis susceptibility: a meta-analysis. Biosci Rep. 2019;39(4). 10.1042/BSR20181960. - PMC - PubMed
    1. Zhang S, et al. Interaction between GDF5 gene polymorphisms and environment factors increased the risk of knee osteoarthritis: a case-control study. Biosci Rep. 2019;39(2). 10.1042/BSR20182423. - PMC - PubMed

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