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Review
. 2020 Nov;21(11):595-610.
doi: 10.1038/s41583-020-0364-5. Epub 2020 Sep 14.

Emergence of abstract rules in the primate brain

Farshad Alizadeh Mansouri  1   2 , David J Freedman  3   4 , Mark J Buckley  5
Affiliations
Review

Emergence of abstract rules in the primate brain

Farshad Alizadeh Mansouri et al. Nat Rev Neurosci. 2020 Nov.

Abstract

Various aspects of human cognition are shaped and enriched by abstract rules, which help to describe, link and classify discrete events and experiences into meaningful concepts. However, where and how these entities emerge in the primate brain and the neuronal mechanisms underlying them remain the subject of extensive research and debate. Evidence from imaging studies in humans and single-neuron recordings in monkeys suggests a pivotal role for the prefrontal cortex in the representation of abstract rules; however, behavioural studies in lesioned monkeys and data from neuropsychological examinations of patients with prefrontal damage indicate substantial functional dissociations and task dependency in the contribution of prefrontal cortical regions to rule-guided behaviour. This Review describes our current understanding of the dynamic emergence of abstract rules in primate cognition, and of the distributed neural network that supports abstract rule formation, maintenance, revision and task-dependent implementation.

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References

    1. Ashby, F. G. & Ell, S. W. The neurobiology of human category learning. Trends Cogn. Sci. 5, 204–210 (2001). - PubMed
    1. Miller, E. K. & Cohen, J. D. An integrative theory of prefrontal cortex function. Annu. Rev. Neurosci. 24, 167–202 (2001). - PubMed
    1. Mansouri, F. A. & Buckley, M. J. Context-dependent adjustments in executive control of goal-directed behaviour: contribution of frontal brain areas to conflict-induced behavioural adjustments in primates. Adv. Neurobiol. 21, 71–83 (2018). - PubMed
    1. Mansouri, F. A., Egner, T. & Buckley, M. J. Monitoring demands for executive control: shared functions between human and nonhuman primates. Trends Neurosci. 40, 15–27 (2017). - PubMed
    1. Mansouri, F. A., Koechlin, E., Rosa, M. G. P. & Buckley, M. J. Managing competing goals — a key role for the frontopolar cortex. Nat. Rev. Neurosci. 18, 645–657 (2017). This comprehensive review proposes that the frontopolar cortex is involved in adjusting the balance between exploitation and exploration in primates. - PubMed

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