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. 2020 Nov;26(11):1691-1693.
doi: 10.1038/s41591-020-1083-1. Epub 2020 Sep 14.

Seasonal coronavirus protective immunity is short-lasting

Arthur W D Edridge  1 , Joanna Kaczorowska  1 , Alexis C R Hoste  2 , Margreet Bakker  1 , Michelle Klein  1 , Katherine Loens  3   4 , Maarten F Jebbink  1 , Amy Matser  5 , Cormac M Kinsella  1 , Paloma Rueda  2 , Margareta Ieven  3 , Herman Goossens  3   4 , Maria Prins  5   6 , Patricia Sastre  2 , Martin Deijs  1 , Lia van der Hoek  7
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Free article

Seasonal coronavirus protective immunity is short-lasting

Arthur W D Edridge et al. Nat Med. 2020 Nov.
Free article

Abstract

A key unsolved question in the current coronavirus disease 2019 (COVID-19) pandemic is the duration of acquired immunity. Insights from infections with the four seasonal human coronaviruses might reveal common characteristics applicable to all human coronaviruses. We monitored healthy individuals for more than 35 years and determined that reinfection with the same seasonal coronavirus occurred frequently at 12 months after infection.

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References

    1. Pyrc, K. et al. Mosaic structure of human coronavirus NL63, one thousand years of evolution. J. Mol. Biol. 364, 964–973 (2006). - DOI
    1. Callow, K. A., Parry, H. F., Sergeant, M. & Tyrrell, D. A. J. The time course of the immune response to experimental coronavirus infection of man. Epidemiol. Infect. 105, 435–446 (1990). - DOI
    1. Van Bilsen, W. P. H. et al. Diverging trends in incidence of HIV versus other sexually transmitted infections in HIV-negative MSM in Amsterdam. AIDS 34, 301–309 (2020). - DOI
    1. Blanchard, E. G., Miao, C., Haupt, T. E., Anderson, L. J. & Haynes, L. M. Development of a recombinant truncated nucleocapsid protein based immunoassay for detection of antibodies against human coronavirus OC43. J. Virol. Methods 177, 100–106 (2011). - DOI
    1. Li, Y., Wang, X. & Nair, H. Global seasonality of human seasonal coronaviruses: a clue for postpandemic circulating season of severe acute respiratory syndrome coronavirus 2? J. Infect. Dis. 222, 1090–1097 (2020).

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