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Review
. 2021 Jan;64(1):22-50.
doi: 10.1007/s11427-020-1700-9. Epub 2020 Sep 11.

Non-coding RNAs: the new central dogma of cancer biology

Phei Er Saw  1 , Xiaoding Xu  1 , Jianing Chen  2 , Er-Wei Song  3   4
Affiliations
Review

Non-coding RNAs: the new central dogma of cancer biology

Phei Er Saw et al. Sci China Life Sci. 2021 Jan.

Abstract

The central dogma of molecular biology states that the functions of RNA revolve around protein translation. Until the last decade, most researches were geared towards characterization of RNAs as intermediaries in protein translation, namely, messenger RNAs (mRNAs) as temporary copies of genetic information, ribosomal RNAs (rRNAs) as a main component of ribosome, or translators of codon sequence (tRNAs). The statistical reality, however, is that these processes account for less than 2% of the genome, and insufficiently explain the functionality of 98% of transcribed RNAs. Recent discoveries have unveiled thousands of unique non-coding RNAs (ncRNAs) and shifted the perception of them from being "junk" transcriptional products to "yet to be elucidated"-and potentially monumentally important-RNAs. Most ncRNAs are now known as key regulators in various networks in which they could lead to specific cellular responses and fates. In major cancers, ncRNAs have been identified as both oncogenic drivers and tumor suppressors, indicating a complex regulatory network among these ncRNAs. Herein, we provide a comprehensive review of the various ncRNAs and their functional roles in cancer, and the pre-clinical and clinical development of ncRNA-based therapeutics. A deeper understanding of ncRNAs could facilitate better design of personalized therapeutics.

Keywords: anti-cancer therapeutics; circRNA; lncRNA; miRNA; non-coding RNAs; personalized intervention.

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References

    1. Abramczyk, H., Surmacki, J., Kopec, M., Olejnik, A.K., Lubecka-Pietruszewska, K., and Fabianowska-Majewska, K. (2015). The role of lipid droplets and adipocytes in cancer. Raman imaging of cell cultures: MCF10A, MCF7, and MDA-MB-231 compared to adipocytes in cancerous human breast tissue. Analyst 140, 2224–2235. - PubMed
    1. Accioly, M.T., Pacheco, P., Maya-Monteiro, C.M., Carrossini, N., Robbs, B.K., Oliveira, S.S., Kaufmann, C., Morgado-Diaz, J.A., Bozza, P.T., and Viola, J.P.B. (2008). Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E2 synthesis in colon cancer cells. Cancer Res 68, 1732–1740. - PubMed
    1. Akerman, M.E., Chan, W.C.W., Laakkonen, P., Bhatia, S.N., and Ruoslahti, E. (2002). Nanocrystal targeting in vivo. Proc Natl Acad Sci USA 99, 12617–12621. - PubMed
    1. Al-Hajj, M., Wicha, M.S., Benito-Hernandez, A., Morrison, S.J., and Clarke, M.F. (2003). Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100, 3983–3988. - PubMed
    1. Androulidaki, A., Iliopoulos, D., Arranz, A., Doxaki, C., Schworer, S., Zacharioudaki, V., Margioris, A.N., Tsichlis, P.N., and Tsatsanis, C. (2009). The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity 31, 220–231. - PubMed - PMC

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