Hepatic Stellate Cell Senescence in Liver Tumorigenesis
- PMID: 32931043
- DOI: 10.1002/hep.31556
Hepatic Stellate Cell Senescence in Liver Tumorigenesis
Comment on
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FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome.Nat Cell Biol. 2020 Jun;22(6):728-739. doi: 10.1038/s41556-020-0511-2. Epub 2020 May 4. Nat Cell Biol. 2020. PMID: 32367049 Free PMC article.
References
-
- Villanueva A. Hepatocellular carcinoma. N Engl J Med 2019;380:1450‐1462.
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- Li F, Huangyang P, Burrows M, Guo K, Riscal R, Godfrey J, et al. FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome. Nat Cell Biol 2020;22:728‐739.
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- Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, et al. Cellular senescence: defining a path forward. Cell 2019;179:813‐827.
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- Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, Oyadomari S, et al. Obesity‐induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 2013;499:97‐101.
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- Wakita M, Takahashi A, Sano O, Loo TM, Imai Y, Narukawa M, et al. A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells. Nat Commun 2020;11:1935.
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