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Comment
. 2020 Sep 14;38(3):311-313.
doi: 10.1016/j.ccell.2020.08.012.

Same Script, Different Cast: Different Cell Origins Shape Molecular Features and Therapeutic Response in Glioblastoma

Sihan Wu  1 , Paul S Mischel  2
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Free article
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Same Script, Different Cast: Different Cell Origins Shape Molecular Features and Therapeutic Response in Glioblastoma

Sihan Wu et al. Cancer Cell. .
Free article

Abstract

Glioblastoma is heterogeneous in the molecular subtypes based on transcriptomic classification. In this issue of Cancer Cell, Wang et al. define a cell-lineage-based stratification model for glioblastoma, highlighting how the cell of origin generates distinct molecular landscapes and therapeutic vulnerabilities from identical driver mutations.

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Conflict of interest statement

Declaration of Interests P.S.M. is co-founder of Boundless Bio, Inc. and serves as a consultant.

Comment on

  • Cell Lineage-Based Stratification for Glioblastoma.
    Wang Z, Sun D, Chen YJ, Xie X, Shi Y, Tabar V, Brennan CW, Bale TA, Jayewickreme CD, Laks DR, Alcantara Llaguno S, Parada LF. Wang Z, et al. Cancer Cell. 2020 Sep 14;38(3):366-379.e8. doi: 10.1016/j.ccell.2020.06.003. Epub 2020 Jul 9. Cancer Cell. 2020. PMID: 32649888 Free PMC article.

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