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. 2020 Dec;46(12):1564-1571.
doi: 10.1097/DSS.0000000000002712.

Topical Scar Treatment Products for Wounds: A Systematic Review

Benjamin Tran  1 , Jashin J Wu  2 , Desiree Ratner  3 , George Han  4
Affiliations

Topical Scar Treatment Products for Wounds: A Systematic Review

Benjamin Tran et al. Dermatol Surg. 2020 Dec.

Abstract

Background: There is an increasing number of over-the-counter topical products that are said to prevent pathologic scar formation and improve scar cosmesis. However, robust clinical data are lacking to substantiate these claims and to guide selection of topical products.

Objective: To determine the effectiveness of topical scar management products, including silicone gel, Allium cepa onion extract, vitamin E, trolamine, and microporous tape.

Methods and materials: A PubMed search (2005-2019) was performed to identify studies of topical scar management products. Randomized controlled trials (RCTs), quasi-RCTs, meta-analyses, and controlled clinical trials were included for analysis.

Results: A total of 34 trials were included in this study. Of the 16 trials investigating silicone gel sheets, numerous high-quality RCTs found that silicone gel sheets and silicone gels significantly improved scar outcomes. Only a limited number of studies supported the effectiveness of onion extract, vitamin E, trolamine, and microporous tape products.

Conclusion: Silicone gel products are an effective noninvasive treatment to prevent formation of pathologic scars and improve mature scars. Further high-quality studies are needed to elucidate the long-term effectiveness of these therapies.

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References

    1. Bock O, Schmid-Ott G, Malewski P, Mrowietz U. Quality of life of patients with keloid and hypertrophic scarring. Arch Dermatol Res 2006;297:433–8.
    1. Butzelaar L, Ulrich MMW, Mink van der Molen AB, Niessen FB, et al. Currently known risk factors for hypertrophic skin scarring: a review. J Plast Reconstr Aesthet Surg 2016;69:163–9.
    1. Morganroth P, Wilmot AC, Miller C. Over-the-counter scar products for postsurgical patients: disparities between online advertised benefits and evidence regarding efficacy. J Am Acad Dermatol 2009;61:e31–47.
    1. Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev 2003;83:835–70.
    1. Morton LM, Phillips TJ. Wound healing and treating wounds: Differential diagnosis and evaluation of chronic wounds. J Am Acad Dermatol 2016;74:589–605.

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