Multisystem Inflammatory Syndrome Associated With COVID-19 With Neurologic Manifestations in a Child: A Brief Report

doi:10.1097/INF.0000000000002834

Case Reports

. 2020 Oct;39(10):e321-e324.

doi: 10.1097/INF.0000000000002834.

Multisystem Inflammatory Syndrome Associated With COVID-19 With Neurologic Manifestations in a Child: A Brief Report

Milena De Paulis^{1

2}, Danielle Bruna Leal Oliveira³, Rodolfo P Vieira^{4

5}, Isabella Coutinho Pinto¹, Rafael Rahal Guaragna Machado³, Mariana Pauferro Cavalcanti¹, Camila Pereira Soares³, Ananda Medeiros Pereira de Araujo¹, Danielle Bastos Araujo³, Andre Luis Lacerda Bachi^{6

7}, Fabyano Bruno Leal³, Erick Gustavo Dorlass³, Alfredo Elias Gilio^{1

2}, Edison Luiz Durigon³, Eliane Roseli Barreira^{1

8}

Affiliations

¹ From the Division of Pediatrics, University Hospital, University of Sao Paulo - SP, Sao Paulo, Brazil.
² Emergency Department, Hospital Israelita Albert Einstein, Sao Paulo - SP, Brazil.
³ Laboratory of Molecular and Clinical Virology, Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo - SP, Sao Paulo, Brazil.
⁴ Department of Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo (UNIFESP), Santos - SP, Brazil.
⁵ Department of Bioengineering, University of Brazil, Sao Paulo - SP, Brazil.
⁶ Post-graduate Program in Health Sciences, Santo Amaro University, Sao Paulo - SP, Brazil.
⁷ Department of Otorhinolaryngology, Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
⁸ University Nove de Julho, Sao Paulo - SP, Brazil.

PMID: 32932334
DOI: 10.1097/INF.0000000000002834

Case Reports

Multisystem Inflammatory Syndrome Associated With COVID-19 With Neurologic Manifestations in a Child: A Brief Report

Milena De Paulis et al. Pediatr Infect Dis J. 2020 Oct.

. 2020 Oct;39(10):e321-e324.

doi: 10.1097/INF.0000000000002834.

Authors

Affiliations

¹ From the Division of Pediatrics, University Hospital, University of Sao Paulo - SP, Sao Paulo, Brazil.
² Emergency Department, Hospital Israelita Albert Einstein, Sao Paulo - SP, Brazil.
³ Laboratory of Molecular and Clinical Virology, Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo - SP, Sao Paulo, Brazil.
⁴ Department of Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo (UNIFESP), Santos - SP, Brazil.
⁵ Department of Bioengineering, University of Brazil, Sao Paulo - SP, Brazil.
⁶ Post-graduate Program in Health Sciences, Santo Amaro University, Sao Paulo - SP, Brazil.
⁷ Department of Otorhinolaryngology, Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
⁸ University Nove de Julho, Sao Paulo - SP, Brazil.

PMID: 32932334
DOI: 10.1097/INF.0000000000002834

Abstract

Although first considered a benign infection, recent studies have disclosed severe and potentially lethal inflammatory manifestations of COVID-19 in children. We report the case of a 4-year-old child with a post-infectious multisystem inflammatory syndrome associated with COVID-19, with a Kawasaki-like shock and prominent neurologic features, for whom a cytokine storm and reduced brain-derived neurotrophic factor were well documented.

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References

1. Feldstein LR, Rose EB, Horwitz SM, et al. Multisystem inflammatory syndrome in U.S. children and adolescents. N Engl J Med. 2020;383:334–346.
1. Toubiana J, Poirault C, Corsia A, et al. Kawasaki-like multisystem inflammatory syndrome in children during the COVID-19 pandemic in Paris, France: prospective observational study. BMJ. 2020;369:m2094.
1. Belhadjer Z, Bonnet D. Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic. Circulation. 2020;142:429–436.
1. Porritt RA, Markman JL, Maruyama D, et al. Interleukin-1 beta-mediated sex differences in Kawasaki disease vasculitis development and response to treatment. Arterioscler Thromb Vasc Biol. 2020;40:802–818.
1. McCrindle BW, Manlhiot C. SARS-CoV-2 -related inflammatory multisystem syndrome in children different or shared etiology and pathophysiology as Kawasaki disease? JAMA. 2020;324:246–248.

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[1] Feldstein LR, Rose EB, Horwitz SM, et al. Multisystem inflammatory syndrome in U.S. children and adolescents. N Engl J Med. 2020;383:334–346.

[2] Feldstein LR, Rose EB, Horwitz SM, et al. Multisystem inflammatory syndrome in U.S. children and adolescents. N Engl J Med. 2020;383:334–346.

[3] Toubiana J, Poirault C, Corsia A, et al. Kawasaki-like multisystem inflammatory syndrome in children during the COVID-19 pandemic in Paris, France: prospective observational study. BMJ. 2020;369:m2094.

[4] Toubiana J, Poirault C, Corsia A, et al. Kawasaki-like multisystem inflammatory syndrome in children during the COVID-19 pandemic in Paris, France: prospective observational study. BMJ. 2020;369:m2094.

[5] Belhadjer Z, Bonnet D. Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic. Circulation. 2020;142:429–436.

[6] Belhadjer Z, Bonnet D. Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic. Circulation. 2020;142:429–436.

[7] Porritt RA, Markman JL, Maruyama D, et al. Interleukin-1 beta-mediated sex differences in Kawasaki disease vasculitis development and response to treatment. Arterioscler Thromb Vasc Biol. 2020;40:802–818.

[8] Porritt RA, Markman JL, Maruyama D, et al. Interleukin-1 beta-mediated sex differences in Kawasaki disease vasculitis development and response to treatment. Arterioscler Thromb Vasc Biol. 2020;40:802–818.

[9] McCrindle BW, Manlhiot C. SARS-CoV-2 -related inflammatory multisystem syndrome in children different or shared etiology and pathophysiology as Kawasaki disease? JAMA. 2020;324:246–248.

[10] McCrindle BW, Manlhiot C. SARS-CoV-2 -related inflammatory multisystem syndrome in children different or shared etiology and pathophysiology as Kawasaki disease? JAMA. 2020;324:246–248.

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Multisystem Inflammatory Syndrome Associated With COVID-19 With Neurologic Manifestations in a Child: A Brief Report

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Multisystem Inflammatory Syndrome Associated With COVID-19 With Neurologic Manifestations in a Child: A Brief Report

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