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Case Reports
. 2020 Oct;39(10):e321-e324.
doi: 10.1097/INF.0000000000002834.

Multisystem Inflammatory Syndrome Associated With COVID-19 With Neurologic Manifestations in a Child: A Brief Report

Milena De Paulis  1   2 , Danielle Bruna Leal Oliveira  3 , Rodolfo P Vieira  4   5 , Isabella Coutinho Pinto  1 , Rafael Rahal Guaragna Machado  3 , Mariana Pauferro Cavalcanti  1 , Camila Pereira Soares  3 , Ananda Medeiros Pereira de Araujo  1 , Danielle Bastos Araujo  3 , Andre Luis Lacerda Bachi  6   7 , Fabyano Bruno Leal  3 , Erick Gustavo Dorlass  3 , Alfredo Elias Gilio  1   2 , Edison Luiz Durigon  3 , Eliane Roseli Barreira  1   8
Affiliations
Case Reports

Multisystem Inflammatory Syndrome Associated With COVID-19 With Neurologic Manifestations in a Child: A Brief Report

Milena De Paulis et al. Pediatr Infect Dis J. 2020 Oct.

Abstract

Although first considered a benign infection, recent studies have disclosed severe and potentially lethal inflammatory manifestations of COVID-19 in children. We report the case of a 4-year-old child with a post-infectious multisystem inflammatory syndrome associated with COVID-19, with a Kawasaki-like shock and prominent neurologic features, for whom a cytokine storm and reduced brain-derived neurotrophic factor were well documented.

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References

    1. Feldstein LR, Rose EB, Horwitz SM, et al. Multisystem inflammatory syndrome in U.S. children and adolescents. N Engl J Med. 2020;383:334–346.
    1. Toubiana J, Poirault C, Corsia A, et al. Kawasaki-like multisystem inflammatory syndrome in children during the COVID-19 pandemic in Paris, France: prospective observational study. BMJ. 2020;369:m2094.
    1. Belhadjer Z, Bonnet D. Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic. Circulation. 2020;142:429–436.
    1. Porritt RA, Markman JL, Maruyama D, et al. Interleukin-1 beta-mediated sex differences in Kawasaki disease vasculitis development and response to treatment. Arterioscler Thromb Vasc Biol. 2020;40:802–818.
    1. McCrindle BW, Manlhiot C. SARS-CoV-2 -related inflammatory multisystem syndrome in children different or shared etiology and pathophysiology as Kawasaki disease? JAMA. 2020;324:246–248.

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