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Review
. 2020 Sep 12;21(18):6686.
doi: 10.3390/ijms21186686.

The Role of Sirtuins in Kidney Diseases

Yu Ah Hong  1 , Ji Eun Kim  2 , Minjee Jo  2 , Gang-Jee Ko  2
Affiliations
Review

The Role of Sirtuins in Kidney Diseases

Yu Ah Hong et al. Int J Mol Sci. .

Abstract

Sirtuins (SIRTs) are class III histone deacetylases (HDACs) that play important roles in aging and a wide range of cellular functions. Sirtuins are crucial to numerous biological processes, including proliferation, DNA repair, mitochondrial energy homeostasis, and antioxidant activity. Mammals have seven different sirtuins, SIRT1-7, and the diverse biological functions of each sirtuin are due to differences in subcellular localization, expression profiles, and cellular substrates. In this review, we summarize research advances into the role of sirtuins in the pathogenesis of various kidney diseases including acute kidney injury, diabetic kidney disease, renal fibrosis, and kidney aging along with the possible underlying molecular mechanisms. The available evidence indicates that sirtuins have great potential as novel therapeutic targets for the prevention and treatment of kidney diseases.

Keywords: acute kidney injury; aging kidney; chronic kidney disease; diabetic nephropathy; kidney; sirtuins.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Implication of sirtuins in various kidney diseases associated with variable cellular location of sirtuins and associated pathways. The types of lines (solid line: attenuation of disease, dotted line: aggravation of disease, dash line: controversial) between each sirtuin with kidney disease were based on previous studies.
See this image and copyright information in PMC

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