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. 2020 Sep;17(9):934-940.
doi: 10.30773/pi.2020.0133. Epub 2020 Sep 17.

Positive Association of Human SHC3 Gene with Schizophrenia in a Northeast Chinese Han Population

Ye Lv  1 , Yang Sun  2 , Guan-Yu Wang  3 , Jian Yin  3 , Cheng-Jie Li  1 , Yi-Yang Luo  1 , Zhi-Lin Luan  1
Affiliations

Positive Association of Human SHC3 Gene with Schizophrenia in a Northeast Chinese Han Population

Ye Lv et al. Psychiatry Investig. 2020 Sep.

Abstract

Objective: Schizophrenia is one of the most devastating neuropsychiatric disorders. Genetic epidemiological studies have confirmed that schizophrenia is a genetic disease. Genes promoting neurodevelopment may be potential candidates for schizophrenia. As an adaptor linking a number of tyrosine kinase receptors in multiple intracellular signaling cascades, Src homology 2 domain containing transforming protein 3 (SHC3) is a member of the Shc-like adaptor protein family, and expressed predominantly in the mature neurons of the central nervous system (CNS). In the present study, we aimed to investigate the association of SHC3 and schizophrenia.

Methods: An independent case-control association study was performed in a sample including 710 schizophrenia patients and 1314 healthy controls from a Northeast Chinese Han population.

Results: The allelic and genotypic association analyses showed that four SNPs in SHC3 significantly associated with schizophrenia (rs2316280, rs4877041, rs944485 and rs7021743). The haplotype composing of these four SNPs also showed significantly individual and global association with schizophrenia.

Conclusion: Our present results suggest SHC3 as a susceptibility gene for schizophrenia.

Keywords: Association; Neurodevelopment; SHC3; Schizophrenia; Single nucleotide polymorphism (SNP).

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Conflict of interest statement

The authors have no potential conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
SHC3 gene expression in different tissues. TPM on the vertical axis represents the transcript quantification value, and the horizontal axis represents different tissues. The SHC3 gene was highly expressed in brain tissue compared with other tissues.
See this image and copyright information in PMC

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