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Review
. 2020 Sep 15;11(1):400.
doi: 10.1186/s13287-020-01921-2.

Unraveling the therapeutic effects of mesenchymal stem cells in asthma

Fatemeh Mirershadi  1   2 , Mahdi Ahmadi  1   3 , Aysa Rezabakhsh  4 , Hadi Rajabi  5   6 , Reza Rahbarghazi  7   8 , Rana Keyhanmanesh  9   10   11
Affiliations
Review

Unraveling the therapeutic effects of mesenchymal stem cells in asthma

Fatemeh Mirershadi et al. Stem Cell Res Ther. .

Abstract

Asthma is a chronic inflammatory disease associated with airway hyper-responsiveness, chronic inflammatory response, and excessive structural remodeling. The current therapeutic strategies in asthmatic patients are based on controlling the activity of type 2 T helper lymphocytes in the pulmonary tissue. However, most of the available therapies are symptomatic and expensive and with diverse side outcomes in which the interruption of these modalities contributes to the relapse of asthmatic symptoms. Up to date, different reports highlighted the advantages and beneficial outcomes regarding the transplantation of different stem cell sources, and relevant products from for the diseases' alleviation and restoration of injured sites. However, efforts to better understand by which these cells elicit therapeutic effects are already underway. The precise understanding of these mechanisms will help us to translate stem cells into the clinical setting. In this review article, we described current knowledge and future perspectives related to the therapeutic application of stem cell-based therapy in animal models of asthma, with emphasis on the underlying therapeutic mechanisms.

Keywords: Asthma; Cellular and molecular mechanisms; Regeneration; Stem cells.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Pleiotropic effects of stem cells on pulmonary asthmatic niche via different mechanisms
See this image and copyright information in PMC

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