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Review
. 2021 Apr;12(3):343-351.
doi: 10.1016/j.jgo.2020.09.010. Epub 2020 Sep 12.

The acceleration of ageing in older patients with cancer

Jaidyn Muhandiramge  1 , Suzanne Orchard  2 , Andrew Haydon  3 , John Zalcberg  4
Affiliations
Review

The acceleration of ageing in older patients with cancer

Jaidyn Muhandiramge et al. J Geriatr Oncol. 2021 Apr.

Abstract

Older cancer survivors may experience ageing at an accelerated rate when compared to their similar-aged, cancer-free counterparts. Ageing is undoubtedly a significant risk factor for cancer. There is evidence to suggest, however, that this relationship may in fact be bidirectional, with cancer and its treatments contributing to the ageing process. In this review, we outline the current literature linking cancer and anti-cancer therapy to adverse ageing outcomes and explore what additional research is needed in order to conclusively define cancer and its treatment as an accelerator of ageing.

Keywords: Accelerated ageing; Ageing; Cancer; Chronic disease; Cognitive decline; Frailty; Functional decline; Older patients.

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Conflict of interest statement

Declaration of Competing Interest The authors have no conflicts of interest to report.

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