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Review

. 2020 Sep 15;5(1):203.

doi: 10.1038/s41392-020-00310-8.

Convalescent plasma therapy for COVID-19: a tried-and-true old strategy?

Yongzhi Xi¹

Affiliations

Affiliation

¹ Department of Immunology and National Center for Biomedicine Analysis, Fifth Medical Center of Chinese PLA General Hospital, No. 8, Dongda Ave, Fengtai District, 100071, Beijing, P.R. China. xiyz@yahoo.com.

PMID: 32934211
PMCID: PMC7490573
DOI: 10.1038/s41392-020-00310-8

Review

Convalescent plasma therapy for COVID-19: a tried-and-true old strategy?

Yongzhi Xi. Signal Transduct Target Ther. 2020.

. 2020 Sep 15;5(1):203.

doi: 10.1038/s41392-020-00310-8.

Author

Yongzhi Xi¹

Affiliation

¹ Department of Immunology and National Center for Biomedicine Analysis, Fifth Medical Center of Chinese PLA General Hospital, No. 8, Dongda Ave, Fengtai District, 100071, Beijing, P.R. China. xiyz@yahoo.com.

PMID: 32934211
PMCID: PMC7490573
DOI: 10.1038/s41392-020-00310-8

No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares no competing interests.

Figures

Fig. 1 — Fig. 1. The immune mechanisms of ADE mediated by viral infections.
a–c Mechanisms underlying the antibody-dependent enhancement (ADE) of viral infections mediated by the Fcγ receptor and complement-dependent pathways, and the relationship between ADE occurrence and antibody titer. Figure partially adapted from ref.

See this image and copyright information in PMC

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References

1. WHO. Coronavirus Disease 2019 (COVID-19) Situation Report-209 (World Health Organization, Geneva, 2020).
1. Baden LR, Rubin EJ. Covid-19—the search for effective therapy. N. Engl. J. Med. 2020;382:1851–1852. doi: 10.1056/NEJMe2005477. - DOI - PMC - PubMed
1. National Health Commission of the People’s Republic of China. Official Guidance for Prevention, Control, Diagnosis and Management for COVID-19 Patients (version 6.0). http://www.nhc.gov.cn/yzygj/s7653p/202002/8334a8326dd94d329df351d7da8aef... (2020) (in Chinese).
1. NIH. Coronavirus Disease 2019 (COVID-19) Treatment Guidelines (2020) (NIH, 2020). - PubMed
1. Shen C, et al. Treatment of 5 critically ill patients with COVID-19 with convalescent plasma. JAMA. 2020;323:1582–1589. doi: 10.1001/jama.2020.4783. - DOI - PMC - PubMed

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