. 2021 Feb;41(2):247-254.

doi: 10.1038/s41372-020-00799-5. Epub 2020 Sep 15.

Blood myo-inositol concentrations in preterm and term infants

Luc P Brion¹, Dale L Phelps², Robert M Ward³, Tracy L Nolen⁴, N Mikko K Hallman⁵, Abhik Das⁶, Daniel J Zaccaro⁴, M Bethany Ball⁷, Kristi L Watterberg⁸, Ivan D Frantz 3rd⁹, C Michael Cotten¹⁰, Brenda B Poindexter¹¹, William Oh¹², Ralph A Lugo¹³, Krisa P Van Meurs⁷, T Michael O'Shea¹⁴, Kristin M Zaterka-Baxter⁴, Rosemary D Higgins^{15

16}; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

Collaborators, Affiliations

Collaborators

Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network:
Alan H Jobe, Michael S Caplan, Abbot R Laptook, Angelita M Hensman, Ronald N Goldberg, Kathy J Auten, Stephanie Wilson Archer, James A Lemons, Dianne E Herron, Leslie Dawn Wilson, W Kenneth Poole, Jeanette O'Donnell Auman, Betty K Hastings, Norbert T Kadima, James W Pickett 2nd, Lisa A Wrage, Patricia Chess, Linda J Reubens, Erica Burnell, Mary Rowan, Cassandra A Horihan, Nancy J Peters, Richard A Ehrenkranz, Patricia Gettner, Monica Konstantino, Joann Poulsen, Janet Taft

Affiliations

¹ Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. luc.brion@utsouthwestern.edu.
² School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA.
³ Department of Pediatrics, Division of Neonatology, University of Utah School of Medicine, Salt Lake City, UT, USA.
⁴ Statistics and Epidemiology Unit, RTI International, Research Triangle Park, NC, USA.
⁵ PEDEGO Research Center, and MRC Oulu, University of Oulu, and Oulu University Hospital, Oulu, Finland.
⁶ Statistics and Epidemiology Unit, RTI International, Rockville, USA.
⁷ Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA.
⁸ Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
⁹ Department of Pediatrics, Division of Newborn Medicine, Floating Hospital for Children, Tufts Medical Center, Boston, MA, USA.
¹⁰ Department of Pediatrics, Duke University, Durham, NC, USA.
¹¹ Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
¹² Department of Pediatrics, Women & Infants' Hospital, Brown University, Providence, RI, USA.
¹³ Department of Pharmacy Practice, Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, TN, USA.
¹⁴ Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
¹⁵ Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
¹⁶ College of Health and Human Services, George Mason University, Fairfax, VA, USA.

PMID: 32934363
PMCID: PMC7889639
DOI: 10.1038/s41372-020-00799-5

Blood myo-inositol concentrations in preterm and term infants

Luc P Brion et al. J Perinatol. 2021 Feb.

. 2021 Feb;41(2):247-254.

doi: 10.1038/s41372-020-00799-5. Epub 2020 Sep 15.

Authors

Collaborators

Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network:
Alan H Jobe, Michael S Caplan, Abbot R Laptook, Angelita M Hensman, Ronald N Goldberg, Kathy J Auten, Stephanie Wilson Archer, James A Lemons, Dianne E Herron, Leslie Dawn Wilson, W Kenneth Poole, Jeanette O'Donnell Auman, Betty K Hastings, Norbert T Kadima, James W Pickett 2nd, Lisa A Wrage, Patricia Chess, Linda J Reubens, Erica Burnell, Mary Rowan, Cassandra A Horihan, Nancy J Peters, Richard A Ehrenkranz, Patricia Gettner, Monica Konstantino, Joann Poulsen, Janet Taft

Affiliations

¹ Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. luc.brion@utsouthwestern.edu.
² School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA.
³ Department of Pediatrics, Division of Neonatology, University of Utah School of Medicine, Salt Lake City, UT, USA.
⁴ Statistics and Epidemiology Unit, RTI International, Research Triangle Park, NC, USA.
⁵ PEDEGO Research Center, and MRC Oulu, University of Oulu, and Oulu University Hospital, Oulu, Finland.
⁶ Statistics and Epidemiology Unit, RTI International, Rockville, USA.
⁷ Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA.
⁸ Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
⁹ Department of Pediatrics, Division of Newborn Medicine, Floating Hospital for Children, Tufts Medical Center, Boston, MA, USA.
¹⁰ Department of Pediatrics, Duke University, Durham, NC, USA.
¹¹ Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
¹² Department of Pediatrics, Women & Infants' Hospital, Brown University, Providence, RI, USA.
¹³ Department of Pharmacy Practice, Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, TN, USA.
¹⁴ Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
¹⁵ Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
¹⁶ College of Health and Human Services, George Mason University, Fairfax, VA, USA.

PMID: 32934363
PMCID: PMC7889639
DOI: 10.1038/s41372-020-00799-5

Abstract

Objective: To describe relationship between cord blood (representing fetal) myo-inositol concentrations and gestational age (GA) and to determine trends of blood concentrations in enterally and parenterally fed infants from birth to 70 days of age.

Design/methods: Samples were collected in 281 fed or unfed infants born in 2005 and 2006. Myo-inositol concentrations were displayed in scatter plots and analyzed with linear regression models of natural log-transformed values.

Results: In 441 samples obtained from 281 infants, myo-inositol concentrations varied from nondetectable to 1494 μmol/L. Cord myo-inositol concentrations decreased an estimated 11.9% per week increase in GA. Postnatal myo-inositol concentrations decreased an estimated 14.3% per week increase in postmenstrual age (PMA) and were higher for enterally fed infants compared to unfed infants (51% increase for fed vs. unfed infants).

Conclusions: Fetal myo-inositol concentrations decreased with increasing GA. Postnatal concentrations decreased with increasing PMA and were higher among enterally fed than unfed infants.

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Conflict of interest statement

Conflict of interest The authors declare that they have no conflict of interest.

Figures

Fig. 1. Cord *myo*-inositol concentration with prediction curves resulting linear regression models of natural log-transformed *myo*inositol concentration with left censoring by gestational age at birth (weeks).
Left-censored includes BQL, below quantifiable limit (<100 μmol/L), and not detected, 0–50 μmol/L.

Fig. 2. Serial *myo*-inositol concentration with prediction curves resulting linear regression models of natural log-transformed *myo*inositol concentration with left censoring by PMA (weeks) and feeding category (enterally fed, upper panel; NPO, lower panel).
Left-censored includes BQL, below quantifiable limit (<100 μmol/L), and not detected, 0–50 μmol/L. For the linear model, a random effect for infant was included to account for correlation between observations within infant.

See this image and copyright information in PMC

References

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Blood myo-inositol concentrations in preterm and term infants

Collaborators

Affiliations

Blood myo-inositol concentrations in preterm and term infants

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

Figures

References

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