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. 2020 Aug 31;9(1):854.
doi: 10.4102/ajlm.v9i1.854. eCollection 2020.

Herpes simplex virus-2 infections in pregnant women from South Africa: Evaluation of the ImmunoFLOW rapid test

Shanthie Govender  1 , Lungile Mbambo  1 , Makandwe Nyirenda  2 , Motshedisi Sebitloane  3 , Nathlee Abbai  1
Affiliations

Herpes simplex virus-2 infections in pregnant women from South Africa: Evaluation of the ImmunoFLOW rapid test

Shanthie Govender et al. Afr J Lab Med. .

Abstract

The diagnostic performance of ImmunoFLOW, a rapid test for detecting herpes simplex virus type-2 (HSV-2) infections, was investigated in 248 antenatal women. Approximately one hundred and seventy-seven (71%) of the enrolled women were infected with HSV-2. Sero-positivity was associated with older age ([≥ 30 years] 104/177, 58%), having a secondary level of education but not tertiary level of education (125/177, 70.6%), and being unmarried (150/177, 84.7%). The sensitivity of the ImmunoFLOW test in relation to the HerpeSelect HSV-2 enzyme-linked immunosorbent assay was 89.7% and specificity was 96.2%. The ImmunoFLOW therefore can serve as a valuable test in screening for HSV-2 infections in pregnant women.

Keywords: HSV-2 infection; South Africa; pregnant women; rapid test.

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Conflict of interest statement

The authors declared no potential conflicts of interest with respect to the research, authorship or publication of this article.

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