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Editorial
. 2021 Jan 15;203(2):157-158.
doi: 10.1164/rccm.202008-3294ED.

Antibiotic Use in Sepsis: How and Why Less Can Really Mean More (Survival)

Michael S Niederman  1   2
Affiliations
Editorial

Antibiotic Use in Sepsis: How and Why Less Can Really Mean More (Survival)

Michael S Niederman. Am J Respir Crit Care Med. .
No abstract available

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Comment on

  • Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis. A Randomized Trial.
    Kyriazopoulou E, Liaskou-Antoniou L, Adamis G, Panagaki A, Melachroinopoulos N, Drakou E, Marousis K, Chrysos G, Spyrou A, Alexiou N, Symbardi S, Alexiou Z, Lagou S, Kolonia V, Gkavogianni T, Kyprianou M, Anagnostopoulos I, Poulakou G, Lada M, Makina A, Roulia E, Koupetori M, Apostolopoulos V, Petrou D, Nitsotolis T, Antoniadou A, Giamarellos-Bourboulis EJ. Kyriazopoulou E, et al. Am J Respir Crit Care Med. 2021 Jan 15;203(2):202-210. doi: 10.1164/rccm.202004-1201OC. Am J Respir Crit Care Med. 2021. PMID: 32757963 Free PMC article. Clinical Trial.

References

    1. Zasowski EJ, Bassetti M, Blasi F, Goossens H, Rello J, Sotgiu G, et al. A systematic review of the effect of delayed appropriate antibiotic treatment on the outcomes of patients with severe bacterial infections. Chest. 2020;158:929–938. - PubMed
    1. Seok H, Jeon JH, Park DW. Antimicrobial therapy and antimicrobial stewardship in sepsis. Infect Chemother. 2020;52:19–30. - PMC - PubMed
    1. Schuetz P, Wirz Y, Sager R, Christ-Crain M, Stolz D, Tamm M, et al. Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis. Lancet Infect Dis. 2018;18:95–107. - PubMed
    1. Bouadma L, Luyt CE, Tubach F, Cracco C, Alvarez A, Schwebel C, et al. PRORATA trial group. Use of procalcitonin to reduce patients’ exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial. Lancet. 2010;375:463–474. - PubMed
    1. de Jong E, van Oers JA, Beishuizen A, Vos P, Vermeijden WJ, Haas LE, et al. Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial. Lancet Infect Dis. 2016;16:819–827. - PubMed