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Review
. 2021 Mar 4;17(3):620-637.
doi: 10.1080/21645515.2020.1812313. Epub 2020 Sep 16.

Leveraging on the genomics and immunopathology of SARS-CoV-2 for vaccines development: prospects and challenges

Idris Nasir Abdullahi  1 , Anthony Uchenna Emeribe  2 , Hafeez Aderinsayo Adekola  3 , Sharafudeen Dahiru Abubakar  1 , Amos Dangana  4 , Halima Ali Shuwa  5 , Sunday Theophilus Nwoba  6 , Jelili Olaide Mustapha  7 , Muyideen Titilope Haruna  8 , Kafayat Adepeju Olowookere  9 , Olawale Sunday Animasaun  10 , Charles Egede Ugwu  11 , Solomon Oloche Onoja  12 , Abdullahi Sani Gadama  13 , Musa Mohammed  14 , Isa Muhammad Daneji  13 , Dele Ohinoyi Amadu  15 , Peter Elisha Ghamba  16 , Nkechi Blessing Onukegbe  17 , Muhammad Sagir Shehu  18 , Chiladi Isomah  19 , Adamu Babayo  13 , Abdurrahman El-Fulaty Ahmad  1
Affiliations
Review

Leveraging on the genomics and immunopathology of SARS-CoV-2 for vaccines development: prospects and challenges

Idris Nasir Abdullahi et al. Hum Vaccin Immunother. .

Abstract

The incidence and case-fatality rates (CFRs) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, the etiological agent for Coronavirus Disease 2019 (COVID-19), have been rising unabated. Even though the entire world has been implementing infection prevention and control measures, the pandemic continues to spread. It has been widely accepted that preventive vaccination strategies are the public health measures for countering this pandemic. This study critically reviews the latest scientific advancement in genomics, replication pattern, pathogenesis, and immunopathology of SARS-CoV-2 infection and how these concepts could be used in the development of vaccines. We also offer a detailed discussion on the anticipated potency, efficacy, safety, and pharmaco-economic issues that are and will be associated with candidate COVID-19 vaccines.

Keywords: COVID-19; Host-virus interaction; SARS-CoV-2; Vaccine discovery.

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Figures

Figure 1.
Figure 1.
Genomic organization of SARS-CoV-2
See this image and copyright information in PMC

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