Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jun;94(2):443-8.
doi: 10.1111/j.1476-5381.1988.tb11546.x.

Antagonism of N-methylaspartate and synaptic responses of neurones in the rat ventrobasal thalamus by ketamine and MK-801

T E Salt  1 , D G Wilson, S K Prasad
Affiliations

Antagonism of N-methylaspartate and synaptic responses of neurones in the rat ventrobasal thalamus by ketamine and MK-801

T E Salt et al. Br J Pharmacol. 1988 Jun.

Abstract

1. Extracellular single neurone recordings were made in the ventrobasal thalamus of urethane-anaesthetized rats. 2. Iontophoretically and intravenously administered ketamine and MK-801 were found to be selective antagonists of responses of neurones to iontophoretically applied N-methylaspartate. 3. Both antagonists, administered in N-methylaspartate-selective quantities, reduced the synaptic responses of ventrobasal thalamus neurones to a two-second air jet directed at the peripheral receptive field.

PubMed Disclaimer

References

    1. Eur J Pharmacol. 1972 May;18(3):346-52 - PubMed
    1. Annu Rev Pharmacol Toxicol. 1981;21:165-204 - PubMed
    1. Br J Pharmacol. 1981 Jun;73(2):435-42 - PubMed
    1. Anesthesiology. 1982 Feb;56(2):119-36 - PubMed
    1. Br J Pharmacol. 1983 Jun;79(2):565-75 - PubMed

Publication types

LinkOut - more resources