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Comment
. 2020 Sep;69(7):362-364.

PURL: Is it better to take that antihypertensive at night?

Michael Dickman  1
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Comment

PURL: Is it better to take that antihypertensive at night?

Michael Dickman. J Fam Pract. 2020 Sep.

Abstract

A large RCT in a primary care setting comparing bedtime to upon-waking administration of antihypertensives answers the question.

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References

    1. Hermida RC, Crespo JJ, Domínguez-Sardiña M, et al. Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial [published online ahead of print October 22, 2019]. Eur Heart J. 2019;ehz754. doi:10.1093/eurheartj/ehz754. - PubMed
    1. Dorans KS, Mills KT, Liu Y, et al. Trends in prevalence and control of hypertension according to the 2017 American College of Cardiology/American Heart Association (ACC/AHA) guideline. J Am Heart Assoc. 2018;7:e008888. - PMC - PubMed
    1. Hermida RC, Ayala DE, Smolensky MH, et al. Chronotherapy with conventional blood pressure medications improves management of hypertension and reduces cardiovascular and stroke risks. Hypertens Res. 2016;39:277–292. - PubMed
    1. Bowles NP, Thosar SS, Herzig MX, et al. Chronotherapy for hypertension. Curr Hypertens Rep. 2018;20:97. - PMC - PubMed
    1. Zhao P, Xu P, Wan C, et al. Evening versus morning dosing regimen drug therapy for hypertension. Cochrane Database Syst Rev. 2011:CD004184. - PMC - PubMed

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