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Review
. 2021 Apr 1;21(2):155-162.
doi: 10.17305/bjbms.2020.4735.

An insight into osteoarthritis susceptibility: Integration of immunological and genetic background

Debora Stefik  1 , Vladimir Vranic  2 , Nemanja Ivkovic  1 , Dzihan Abazovic  3 , Dusan Maric  4 , Danilo Vojvodic  5 , Gordana Supic  5
Affiliations
Review

An insight into osteoarthritis susceptibility: Integration of immunological and genetic background

Debora Stefik et al. Bosn J Basic Med Sci. .

Abstract

Osteoarthritis (OA) is a progressive degenerative disease that affects all synovial joints, causing the disability of the main locomotor diarthrodial joints. OA pathogenesis is caused by a complex interplay between a number of genetic and environmental risk factors, involved in the early onset and progression of this chronic inflammatory joint disease. Uncovering the underlying immunological and genetic mechanisms will enable an insight into OA pathophysiology and lead to novel and integrative approaches in the treatment of OA patients, together with a reduction of the disease risk, or a delay of its onset in susceptible patients.

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Conflict of interest statement

Conflict of interest statement: The authors declare no conflict of interests

Figures

FIGURE 1
FIGURE 1
Factors implied in osteoarthritis onset, central events, and disease features. OA: Osteoarthritis.
FIGURE 2
FIGURE 2
Normal joint and joint in osteoarthritis. OA: Osteoarthritis; MMPs: Matrix metalloproteinases; ADAMTS: A disintegrin and metalloproteinase with thrombospondin motifs; IL: Interleukin; TNF-α: Tumor necrosis factor α.
See this image and copyright information in PMC

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