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Comment
. 2020 Sep 15;53(3):479-481.
doi: 10.1016/j.immuni.2020.08.006.

Two Roads Diverge in the Sick Liver, Monocytes Travel Both

Ehud Zigmond  1 , Chen Varol  2
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Two Roads Diverge in the Sick Liver, Monocytes Travel Both

Ehud Zigmond et al. Immunity. .
Free article

Abstract

Liver macrophages play critical roles in the pathogenesis of non-alcoholic steatohepatitis (NASH). In this issue of Immunity, Tran et al. and Remmerie et al. reveal that Ly6Chi monocytes in NASH replace dying resident Kupffer cells, while concomitantly are differentiating into distinct lipid associated macrophages.

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