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Comment
. 2020 Sep 15;53(3):484-486.
doi: 10.1016/j.immuni.2020.08.011.

Microglia Get a Little Help from "Th"-eir Friends

Giuseppe Locatelli  1 , Britta Engelhardt  2
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Microglia Get a Little Help from "Th"-eir Friends

Giuseppe Locatelli et al. Immunity. .
Free article

Abstract

The presence of CD4+ T cells in the healthy brain parenchyma remains controversial due to the barrier function of the glia limitans. Pasciuto, Burton, Roca et al. in Cell describe the dynamic recruitment of CD4+ T cells within the brain parenchyma, their unexpected contribution to microglial maturation, and, ultimately, their influence on behavior.

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  • Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.
    Pasciuto E, Burton OT, Roca CP, Lagou V, Rajan WD, Theys T, Mancuso R, Tito RY, Kouser L, Callaerts-Vegh Z, de la Fuente AG, Prezzemolo T, Mascali LG, Brajic A, Whyte CE, Yshii L, Martinez-Muriana A, Naughton M, Young A, Moudra A, Lemaitre P, Poovathingal S, Raes J, De Strooper B, Fitzgerald DC, Dooley J, Liston A. Pasciuto E, et al. Cell. 2020 Aug 6;182(3):625-640.e24. doi: 10.1016/j.cell.2020.06.026. Epub 2020 Jul 22. Cell. 2020. PMID: 32702313 Free PMC article.

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