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. 2020 Sep 16;5(5):e00810-20.
doi: 10.1128/mSphere.00810-20.

No to Neocosmospora: Phylogenomic and Practical Reasons for Continued Inclusion of the Fusarium solani Species Complex in the Genus Fusarium

Kerry O'Donnell  1 , Abdullah M S Al-Hatmi  2 , Takayuki Aoki  3 , Balázs Brankovics  4 , José F Cano-Lira  5   6 , Jeffrey J Coleman  7 , G Sybren de Hoog  8   9 , Antonio Di Pietro  10 , Rasmus J N Frandsen  11 , David M Geiser  12 , Connie F C Gibas  13 , Josep Guarro  14 , Hye-Seon Kim  15 , H Corby Kistler  16 , Imane Laraba  15 , John F Leslie  17 , Manuel S López-Berges  10 , Erik Lysøe  18 , Jacques F Meis  8   9 , Michel Monod  19 , Robert H Proctor  15 , Martijn Rep  20 , Carmen Ruiz-Roldán  10 , Adnan Šišić  21 , Jason E Stajich  22 , Emma T Steenkamp  23 , Brett A Summerell  24 , Theo A J van der Lee  4 , Anne D van Diepeningen  4 , Paul E Verweij  8   9 , Cees Waalwijk  4 , Todd J Ward  15 , Brian L Wickes  25 , Nathan P Wiederhold  13 , Michael J Wingfield  23 , Ning Zhang  26 , Sean X Zhang  27
Affiliations

No to Neocosmospora: Phylogenomic and Practical Reasons for Continued Inclusion of the Fusarium solani Species Complex in the Genus Fusarium

Kerry O'Donnell et al. mSphere. .

Abstract

This article is to alert medical mycologists and infectious disease specialists of recent name changes of medically important species of the filamentous mold FusariumFusarium species can cause localized and life-threating infections in humans. Of the 70 Fusarium species that have been reported to cause infections, close to one-third are members of the Fusarium solani species complex (FSSC), and they collectively account for approximately two-thirds of all reported Fusarium infections. Many of these species were recently given scientific names for the first time by a research group in the Netherlands, but they were misplaced in the genus Neocosmospora In this paper, we present genetic arguments that strongly support inclusion of the FSSC in Fusarium There are potentially serious consequences associated with using the name Neocosmospora for Fusarium species because clinicians need to be aware that fusaria are broadly resistant to the spectrum of antifungals that are currently available.

Keywords: clinical mycology; evolution; fungi; phylogenetics; taxonomy.

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Figures

FIG 1
FIG 1
(A) Partitioned maximum likelihood bootstrapped (ML-BS) phylogeny of Fusarium inferred from exonic sequences of 19 housekeeping genes totaling 54.99 kb; 20.3 kb of characters were parsimony informative characters (PIC). The phylogram was rooted on sequences of two outgroup species, Beauveria bassiana and Trichoderma brevicompactum. Evolutionary relationships among the 12 species complexes that contain clinically relevant fusaria were completely resolved based on ML-BS values between 91 and 100%. The node identified by F1, which represents the generic limits of Fusarium, received 100% ML-BS support based on 5,000 pseudoreplicates of the data conducted with IQ-TREE (27). (B) ML-BS phylogeny of clade 3 of the Fusarium solani species complex (FSSC) inferred from portions of three loci (TEF1, RPB2, and the internal transcribed spacer [ITS] ribosomal DNA [rDNA]). All 23 species implicated in fusarioses of humans and other animals are nested in FSSC clade 3. Numbers on nodes represent ML-BS support based on 5,000 pseudoreplicates of the data. FSSC numbers in brackets represent the ad hoc nomenclature previously used to distinguish species (22). T, ex-type strains; IT, ex-isotype strain; NT, ex-neotype strain.
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References

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