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. 2020 Oct 21;56(82):12427-12430.
doi: 10.1039/d0cc05379a. Epub 2020 Sep 17.

Benzotetramisole catalyzed kinetic resolution of 2H-azirines

Qiupeng Peng  1 , Donghui Guo, Bei Zhang, Lala Liu, Jian Wang
Affiliations

Benzotetramisole catalyzed kinetic resolution of 2H-azirines

Qiupeng Peng et al. Chem Commun (Camb). .

Abstract

An unprecedented benzotetramisole (BTM)-catalyzed kinetic resolution for the efficient synthesis of chiral 2H-azirines is described. This protocol provides two chiral isomers in one step with broad scope, good yield and high enantioselectivity. In addition, the optically pure 2H-azirine products have proven to be useful building blocks for further synthetic transformations.

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