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. 2020 Dec;31(8):522-529.
doi: 10.1097/MBC.0000000000000957.

High prevalence of overweight/obesity in adult persons with hemophilia in Utah and a review of the literature

Ming Y Lim  1 , Guo Wei  2 , Angela P Presson  3 , Paul Bray  1 , George M Rodgers  1
Affiliations

High prevalence of overweight/obesity in adult persons with hemophilia in Utah and a review of the literature

Ming Y Lim et al. Blood Coagul Fibrinolysis. 2020 Dec.

Abstract

: The objectives of this study were firstly to determine the prevalence of overweight/obesity in adult persons with hemophilia in Utah, and to explore the association between age, disease severity and race with body mass index (BMI), and secondly to provide recent data on the prevalence of overweight/obesity in the hemophilia population via a review of the literature. We conducted a retrospective cross section study of adult persons with hemophilia who were seen at a Utah hemophilia treatment center from 1 January 2017 to 31 December 2019. The electronic database PubMed was searched for studies with observation periods from 1 January 2012 to 31 December 2019. The age-adjusted prevalence for overweight/obesity in the adult Utah hemophilia population was higher than the overall Utah population and the general US population. After adjusting for race and age, mild hemophilia was associated with a 7.7% higher BMI (95% confidence interval, 0.023-15.98%, P < 0.05). Review of the literature demonstrated high levels of overweight/obesity in hemophilia communities globally with considerable heterogeneity between studies. Despite increasing awareness, prevalence of overweight/obesity in the hemophilia population remains high in comparison with the general population. There is a critical need to address this issue acutely at hemophilia treatment centers due to the considerable burden of obesity.

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Conflict of interest statement

Conflict-of-interest disclosures

The authors stated that they had no interests which might be perceived as posing a conflict or bias.

Figures

Figure 1.
Figure 1.
Prevalence of being overweight and obese among adult PwH in Utah based on age category, severity of disease and self-reported race * P <0.05
Figure 2.
Figure 2.
Study selection
See this image and copyright information in PMC

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