Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jan;14(1):86-88.
doi: 10.14802/jmd.20062. Epub 2020 Sep 21.

The Case of a Patient with Pantothenate Kinase-Associated Neurodegeneration Presenting with a Prolonged History of Stuttering Speech and a Misdiagnosis of Parkinson's Disease

Prashant A Natteru  1 , Juebin Huang  1
Affiliations

The Case of a Patient with Pantothenate Kinase-Associated Neurodegeneration Presenting with a Prolonged History of Stuttering Speech and a Misdiagnosis of Parkinson's Disease

Prashant A Natteru et al. J Mov Disord. 2021 Jan.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest

The authors have no financial conflicts of interest.

Figures

Figure 1.
Figure 1.
Brain MRI showing bilateral symmetric globus pallidus signal abnormalities, including T1-weighted imaging hyperintensity (A), the “eye-of-the-tiger” sign on fluid-attenuated inversion recovery imaging (B), and a susceptibility artifact on susceptibility-weighted imaging (C). DaTscan indicating normal uptake (D).
See this image and copyright information in PMC

References

    1. Kurian MA, Hayflick SJ. Pantothenate kinase-associated neurodegeneration (PKAN) and PLA2G6-associated neurodegeneration (PLAN): review of two major neurodegeneration with brain iron accumulation (NBIA) phenotypes. Int Rev Neurobiol. 2013;110:49–71. - PMC - PubMed
    1. Hogarth P. Neurodegeneration with brain iron accumulation: diagnosis and management. J Mov Disord. 2015;8:1–13. - PMC - PubMed
    1. Hayflick SJ, Westaway SK, Levinson B, Zhou B, Johnson MA, Ching KH, et al. Genetic, clinical, and radiographic delineation of Hallervorden-Spatz syndrome. N Engl J Med. 2003;348:33–40. - PubMed
    1. Diaz N. Late onset atypical pantothenate-kinase-associated neurodegeneration. Case Rep Neurol Med. 2013;2013:860201. - PMC - PubMed
    1. Chiapparini L, Savoiardo M, D’Arrigo S, Reale C, Zorzi G, Zibordi F, et al. The “eye-of-the-tiger” sign may be absent in the early stages of classic pantothenate kinase associated neurodegeneration. Neuropediatrics. 2011;42:159–162. - PubMed

LinkOut - more resources