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. 2020 Nov;36(11):892-893.
doi: 10.1016/j.tig.2020.08.014. Epub 2020 Aug 26.

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Valerie Bríd O'Leary  1 , Saak Victor Ovsepian  2
Affiliations

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Valerie Bríd O'Leary et al. Trends Genet. 2020 Nov.
No abstract available

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Figures

Figure 1
Figure 1
General Schematic Overview of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 Genome (top) Indicating Loop Formations That Aid Codon Frame-Shifting or Translational Machinary Diversion via Ribosomal Mimicry. Polyproteins (pp1a and pp1ab) holding nonstructural proteins (NSPs) are translated as well as accessory proteins from open reading frames (ORFs) and structural proteins (represented in a modular format). Potential function of the proteins are indicated. Coronavirus transmission from animal to humans is shown including SARS-CoV-2 with unknown intermediate host that causes coronavirus disease 2019 (COVID-19) (in brackets). Adapted with modifications from Loey et al Symmetry 12(4) 651, 2020. Simplified illustration of SARS-CoV-2 structural components and assembled virus which binds to the constitutively expressed angiotensin-converting enzyme (ACE) 2 receptor enabling entry with release of the RNA genome into the host.
Figure 2
Figure 2
Transmission Electron Micrograph of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 Virus Particles, Isolated from a Patient. Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Copyright credit: NIAID.
See this image and copyright information in PMC

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