Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Feb;54(1):105-108.
doi: 10.1016/j.jmii.2020.08.016. Epub 2020 Sep 8.

SARS-CoV-2-induced immunodysregulation and the need for higher clinical suspicion for co-infection and secondary infection in COVID-19 patients

Affiliations

SARS-CoV-2-induced immunodysregulation and the need for higher clinical suspicion for co-infection and secondary infection in COVID-19 patients

Allison Parrill et al. J Microbiol Immunol Infect. 2021 Feb.

Abstract

Cases of co-infection and secondary infection emerging during the current Coronavirus Disease-19 (COVID-19) pandemic are a major public health concern. Such cases may result from immunodysregulation induced by the SARS-CoV-2 virus. Pandemic preparedness must include identification of disease natural history and common secondary infections to implement clinical solutions.

Keywords: COVID-19 [Supplementary Concept]; Co-infection; Immunosuppression; Lymphopenia; Superinfection.

PubMed Disclaimer

References

    1. World Health Organization Weekly Operational Report on Covid-19 9 September 2020. https://www.who.int/docs/default-source/coronaviruse/weekly-updates/wou-... Published September 9, 2020.
    1. Diao B., Wang C., Tan Y., Chen X., Liu Y., Ning L. Reduction and functional exhaustion of T cells in patients with coronavirus disease 2019 (COVID-19) Front Immunol. 2020;11:827. doi: 10.3389/fimmu.2020.00827. - DOI - PMC - PubMed
    1. Wang F., Hou H., Luo Y., Tang G., Wu S., Huang M. The laboratory tests and host immunity of COVID-19 patients with different severity of illness. JCI Insight. 2020;5(10) doi: 10.1172/jci.insight.137799. - DOI - PMC - PubMed
    1. Chen G., Wu D., Guo W., Cao Y., Huang D., Wang H. Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest. 2020;130(5):2620–2629. doi: 10.1172/JCI137244. - DOI - PMC - PubMed
    1. Wang F., Nie J., Wang H., Zhao Q., Xiong Y., Deng L. Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia. J Infect Dis. 2020;221(11):1762–1769. doi: 10.1093/infdis/jiaa150. - DOI - PMC - PubMed