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Comment
. 2020 Oct 29;56(4):2002608.
doi: 10.1183/13993003.02608-2020. Print 2020 Oct.

In vivo demonstration of pulmonary microvascular involvement in COVID-19 using dual-energy computed tomography

Salim Si-Mohamed  1   2 , Nader Chebib  3 , Monica Sigovan  2 , Lea Zumbihl  1   4 , Ségoléne Turquier  3 , Sara Boccalini  1   2 , Loic Boussel  1   2 , Jean-Francois Mornex  3   4   5 , Vincent Cottin  3   4   5 , Philippe Douek  1   2
Affiliations
Comment

In vivo demonstration of pulmonary microvascular involvement in COVID-19 using dual-energy computed tomography

Salim Si-Mohamed et al. Eur Respir J. .

Abstract

In COVID-19 pneumonia, dual-energy computed tomography has shown two patterns of lung perfusion along the course of the disease: an increase in perfusion blood volume (PBV) with ground-glass opacities and a decrease in PBV with consolidation https://bit.ly/2Zh0XcI

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Conflict of interest statement

Conflict of interest: S. Si-Mohamed reports personal fees for consultancy from Boehringer Ingelheim and non-financial support for meeting attendance from Guerbet, outside the submitted work. Conflict of interest: N. Chebib reports non-financial support for meeting attendance from CSL Behring, Actelion, GSK, Boehringer Ingelheim, Roche and MSD, outside the submitted work. Conflict of interest: M. Sigovan has nothing to disclose. Conflict of interest: L. Zumbihl has nothing to disclose. Conflict of interest: S. Turquier has nothing to disclose. Conflict of interest: S. Boccalini has nothing to disclose. Conflict of interest: L. Boussel has nothing to disclose. Conflict of interest: J-F. Mornex reports grants, personal fees and non-financial support from CSL Behring and LFB, personal fees and non-financial support from Actelion, personal fees from Roche, Boehringer Ingelheim, GSK, Novartis, Chiesi and Elivie, outside the submitted work. Conflict of interest: V. Cottin reports personal fees for advisory board work and lectures, and non-financial support for meeting attendance from Actelion, grants, personal fees for consultancy and lectures, and non-financial support for meeting attendance from Boehringer Ingelheim, personal fees for advisory board and data monitoring committee work from Bayer/MSD and Galapagos, personal fees for advisory board work and lectures from Novartis, personal fees for data monitoring and steering committee work, consultancy and lectures, and non-financial support for meeting attendance from Roche/Promedior, personal fees for lectures from Sanofi and AstraZeneca, personal fees for data monitoring committee work from Celgene and Galecto, personal fees for advisory board work from Shionogi, personal fees for steering committee work from Fibrogen, outside the submitted work. Conflict of interest: P. Douek has nothing to disclose.

Figures

FIGURE 1
FIGURE 1
Key imaging features of microvascular involvement in coronavirus disease 2019 (COVID-19) using lung angiography dual-energy computed tomography scans. Perfusion blood volume (PBV) is defined as the ratio between iodine concentration in a pulmonary lobe and iodine concentration in the main pulmonary artery. a) Representative imaging features of the early clinical phase: increased PBV is seen (black arrows, right panel), matching with ground-glass opacities (GGO) (black arrows, left panel), relative to the areas without GGO. b) Representative imaging features of the late clinical phase: decreased PBV is seen (white arrows, right panel), matching with alveolar consolidation (black arrows, left panel), relative to the areas without consolidation. c) Three-dimensional graph of lobar PBV as a function of the presence and extension of GGO and alveolar consolidation. Each dot corresponds to a lobe, the coordinates of which are represented by PBV in the z-axis, GGO extension in x-axis and consolidation extension in y-axis (volumetric extension score, 0: none; 1: 0–25%; 2: 26–50%; 3: 51–75%; 4: 76–100%). Colour grid represents the multiple linear regression plane.
See this image and copyright information in PMC

Comment on

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