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Review
. 2020 Jun 29;9(1):1785161.
doi: 10.1080/20013078.2020.1785161.

Exosome therapeutics for lung regenerative medicine

Kristen Popowski  1   2 , Halle Lutz  1 , Shiqi Hu  1 , Arianna George  3   4 , Phuong-Uyen Dinh  1   2 , Ke Cheng  1   2   5   6
Affiliations
Review

Exosome therapeutics for lung regenerative medicine

Kristen Popowski et al. J Extracell Vesicles. .

Abstract

Exosomes are 30 to 100 nm extracellular vesicles that are secreted by many cell types. Initially viewed as cellular garbage with no biological functions, exosomes are now recognized for their therapeutic potential and used in regenerative medicine. Cell-derived exosomes are released into almost all biological fluids, making them abundant and accessible vesicles for a variety of diseases. These naturally occurring nanoparticles have a wide range of applications including drug delivery and regenerative medicine. Exosomes sourced from a specific tissue have been proven to provide greater therapeutic effects to their native tissue, expanding exosome sources beyond traditional cell lines such as mesenchymal stem cells. However, standardizing production and passing regulations remain obstacles, due to variations in methods and quantification techniques across studies. Additionally, obtaining pure exosomes at sufficient quantities remains difficult due to the heterogeneity of exosomes. In this review, we will underline the uses of exosomes as a therapy and their roles in lung regenerative medicine, as well as current challenges in exosome therapies.

Keywords: Exosome; lung spheroid cell; regenerative medicine; stem cell.

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Figures

Figure 1.
Figure 1.
Schematic of the derivation of lung spheroid cells (LSCs) from whole lung and minimally invasive transbronchial lung biopsies [From Respiratory Research 40].
Figure 2.
Figure 2.
Comparison of exosomal cargo between lung spheroid cell- and mesenchymal cell-derived exosomes [49].
See this image and copyright information in PMC

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