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. 2020 Jun 21;10(3):e99582.
doi: 10.5812/aapm.99582. eCollection 2020 Jun.

Nitroglycerin Plus Morphine on Iv Patient Controlled Analgesia for Abdominal Surgery: The Effect on Postoperative Pain

Seyyed Hasan Karbasy  1 , Azadeh Sekhavati  1 , Amir Sabertanha  1 , BibiFatemeh Shakhsemampour  1
Affiliations

Nitroglycerin Plus Morphine on Iv Patient Controlled Analgesia for Abdominal Surgery: The Effect on Postoperative Pain

Seyyed Hasan Karbasy et al. Anesth Pain Med. .

Abstract

Background: Some studies have reported the effect of nitroglycerin on the reduction of pain after surgery.

Objectives: The primary goal of the current study was to evaluate the addition of nitroglycerin (as a nitric oxide donor) to morphine in patient-controlled analgesia. Besides, its effects on the reduction of pain and stability in hemodynamic indices after abdominal surgery are also investigated.

Methods: The current study was performed on 60 patients as candidates for abdominal surgery. Morphine (0.75 mg/mL) and nitroglycerin plus morphine (morphine 0.5 mg/mL + TNG 15 μg/mL) infusions were used for control and case groups, respectively, with the same induction of anesthesia. The severity of postoperative pain, hemodynamic indices of systolic blood pressure, diastolic pressure, heart rate, respiratory rate, and nausea were measured after surgery (immediately, 2, 6, 12, and 24 hours after surgery).

Results: The pain score decreased for both groups almost similarly. The mean systolic blood pressure was highly reduced in both groups. However, the mean diastolic blood pressure in the control group was considerably lower than that of the case group. Besides, the respiratory rate in the case group dramatically diminished and approached the normal value.

Conclusions: Combined administration of nitroglycerin and morphine had no synergistic effects on reducing postoperative pain. However, it led to more stable hemodynamic indices and improved breathing, without any side effects.

Keywords: Morphine; Nitroglycerin; Pain; Patient-Controlled Analgesia.

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Conflict of interest statement

Conflict of Interests: There was no conflict of interest among the authors.

Figures

Figure 1.
Figure 1.. Flow diagram of study
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References

    1. Miller R, Cohen N, Erikson LI, Fleisher LA, Wiener-Kronish JP, Young WL. Miller's Anesthesia. Philadelphia: Elsevier Sauders; 2015.
    1. Wiffen PJ, McQuay HJ, Edwards JE, Moore RA. Gabapentin for acute and chronic pain. Cochrane Database Syst Rev. 2005;(3):CD005452. doi: 10.1002/14651858.CD005452. - DOI - PubMed
    1. Imani F, Faiz HR, Sedaghat M, Hajiashrafi M. Effects of adding ketamine to fentanyl plus acetaminophen on postoperative pain by patient controlled analgesia in abdominal surgery. Anesth Pain Med. 2014;4(1):e12162. doi: 10.5812/aapm.12162. - DOI - PMC - PubMed
    1. Svedman P, Ingvar M, Gordh T. "Anxiebo", placebo, and postoperative pain. BMC Anesthesiol. 2005;5:9. doi: 10.1186/1471-2253-5-9. - DOI - PMC - PubMed
    1. Imani F, Varrassi G. Ketamine as Adjuvant for Acute Pain Management. Anesth Pain Med. 2019;9(6):e100178. doi: 10.5812/aapm.100178. - DOI - PMC - PubMed

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