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. 2022 Apr;36(7):1842-1850.
doi: 10.1080/14786419.2020.1821015. Epub 2020 Sep 18.

Sarcoroseolides A-D, four undescribed cembranoids from the Red Sea soft coral Sarcophyton roseum

Mohammed M A Ahmed  1   2 , Mohamed A Albadry  2 , Ehab A Ragab  1 , Elsayed M El-Ghaly  1 , Said K Ismail  1 , Zulfiqar Ali  2 , Shabana I Khan  2   3 , Amar G Chittiboyina  2 , Ikhlas A Khan  2   3
Affiliations

Sarcoroseolides A-D, four undescribed cembranoids from the Red Sea soft coral Sarcophyton roseum

Mohammed M A Ahmed et al. Nat Prod Res. 2022 Apr.

Abstract

Four undescribed cembranoids, sarcoroseolides A-D (1-4) along with nine reported related cembranoids (5-13) were isolated from the soft coral Sarcophyton roseum. The chemical structures of sarcoroseolides A-D were elucidated by extensive 1 D and 2 D NMR as well as HR-ESIMS spectroscopic data. Moreover, the geometric and absolute configurations were assigned by the modified Mosher's method and/or NOESY experiments. The extract and the isolated metabolites were evaluated for their potential anti-inflammatory and cytotoxic activities.

Keywords: Sarcophyton roseum; Soft coral; cembranoids; sarcoroseolides A-D.

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