Vitamin C and thiamine for sepsis: time to go back to fundamental principles

Tomoko Fujii^{1

2}, Robert Fowler³, Jean-Louis Vincent⁴

Affiliations

¹ Intensive Care Unit, Jikei University Hospital, 3-19-18, Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan. tofujii-tky@umin.net.
² Australian and New Zealand Intensive Care Research Centre, Monash University School of Public Health and Preventive Medicine, Melbourne, VIC, Australia. tofujii-tky@umin.net.
³ Department of Medicine and Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
⁴ Department of Intensive Care, Erasme University Hospital, Brussels, Belgium.

Editorial

Tomoko Fujii et al. Intensive Care Med. 2020 Nov.

. 2020 Nov;46(11):2061-2063.

doi: 10.1007/s00134-020-06242-9. Epub 2020 Sep 18.

Tomoko Fujii^{1

2}, Robert Fowler³, Jean-Louis Vincent⁴

¹ Intensive Care Unit, Jikei University Hospital, 3-19-18, Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan. tofujii-tky@umin.net.
² Australian and New Zealand Intensive Care Research Centre, Monash University School of Public Health and Preventive Medicine, Melbourne, VIC, Australia. tofujii-tky@umin.net.
³ Department of Medicine and Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
⁴ Department of Intensive Care, Erasme University Hospital, Brussels, Belgium.

No abstract available

Comment on

Combination therapy of vitamin C and thiamine for septic shock: a multi-centre, double-blinded randomized, controlled study.
Hwang SY, Ryoo SM, Park JE, Jo YH, Jang DH, Suh GJ, Kim T, Kim YJ, Kim S, Cho H, Jo IJ, Chung SP, Choi SH, Shin TG, Kim WY; Korean Shock Society (KoSS). Hwang SY, et al. Intensive Care Med. 2020 Nov;46(11):2015-2025. doi: 10.1007/s00134-020-06191-3. Epub 2020 Aug 11. Intensive Care Med. 2020. PMID: 32780166 Free PMC article. Clinical Trial.

1. Moskowitz A, Andersen LW, Huang DT et al (2018) Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation. Crit Care 22:283 - DOI - PMC
1. Fujii T, Deane AM, Nair P (2020) Metabolic support in sepsis: corticosteroids and vitamins: the why, the when, the how. Curr Opin Crit Care 26(4):363–368 - PMC
1. Donnino MW, Carney E, Cocchi MN, Barbash I, Chase M, Joyce N et al (2010) Thiamine deficiency in critically ill patients with sepsis. J Crit Care 25(4):576–581 - DOI - PMC
1. Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas J (2017) Hydrocortisone, Vitamin C and thiamine for the treatment of severe sepsis and septic shock: a retrospective before-after study. Chest 151(6):1229–1238 - DOI - PMC
1. Hwang SY, Ryoo SM, Park JE, Jo YH, Jang D-H, Suh GJ et al (2020) Combination therapy of vitamin C and thiamine for septic shock: a multi-centre, double-blind, randomized Controlled Study. Intensive Care Med 2:167–345