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Review
. 2021 Mar;97(3):633-648.
doi: 10.1111/cbdd.13800. Epub 2020 Sep 29.

An overview on synthetic and pharmaceutical prospective of pyrido[2,3-d]pyrimidines scaffold

Pratibha Yadav  1 , Kamal Shah  1
Affiliations
Review

An overview on synthetic and pharmaceutical prospective of pyrido[2,3-d]pyrimidines scaffold

Pratibha Yadav et al. Chem Biol Drug Des. 2021 Mar.

Abstract

Pyrido[2,3-d]pyrimidine, a fused hetero-bicyclic nucleus containing pyridine and pyrimidine rings has attained the momentary attention in the sphere of multicomponent synthetic protocol and medicinal chemist. Pyrido[2,3-d]pyrimidine derived drugs have manifested diverse pharmacological activities, particularly, anti-inflammatory, cytotoxic, antimicrobial, phosphodiesterase inhibitors and cytokine inhibitors etc. The present review illustrates various modern synthetic strategies adopted, the structure-activity relationship (SAR) aspects and discloses the extensive crucial biological properties (anticancer, anti-infectious, anti-diabetics and CNS agents) of pyrido[2,3-d]pyrimidines.

Keywords: CNS agents; anti-diabetics; anti-infectious; anticancer; pyrido[2,3-d]pyrimidines.

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References

REFERENCES

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