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. 2020 Sep 18;15(9):e0239257.
doi: 10.1371/journal.pone.0239257. eCollection 2020.

The female side of pharmacotherapy for ADHD-A systematic literature review

Francien M Kok  1 , Yvonne Groen  1 , Anselm B M Fuermaier  1 , Oliver Tucha  1   2
Affiliations

The female side of pharmacotherapy for ADHD-A systematic literature review

Francien M Kok et al. PLoS One. .

Abstract

Objective: This comprehensive review examined sex differences in prescription rates and efficacy or effectiveness of pharmacotherapy treatment in girls and women with attention deficit hyperactivity disorder (ADHD), while identifying gaps in the scientific knowledge on this topic.

Method: A rigorous electronic database search was carried out in order to identify all published studies on female-specific effects of stimulants and non-stimulants in the treatment of ADHD. In total, 2672 studies were screened of which 21 studies (seven on prescription rates, 14 on effects of pharmacotherapy) met the inclusion criteria and were included for analysis.

Results: In all seven studies on ADHD prescription rates, girls received significantly less prescriptions than boys, a difference however no longer seen in adults with the exception of one study. Each of the 14 studies on effectiveness / efficacy found at least one sex-difference in the effects of ADHD pharmacotherapy.

Conclusion: Several sex-differences are demonstrated in the prescription, usage and efficacy /effectiveness of both stimulant and non-stimulant ADHD pharmacotherapy. A single daily use of MPH may possibly not be optimal for girls with ADHD and ATX may be a promising medication for girls and women with ADHD. The robustness of this result requires further investigation.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow chart study inclusion process.
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References

    1. American Psychiatric Publishing. Diagnostic and Statistical Manual of Mental Disorders: DSM- V 5th ed Washington, DC: Author; 2013.
    1. Arnett A. B., Pennington B. F., Willcutt E. G., DeFries J. C., & Olson R. K. (2015). Sex differences in ADHD symptom severity. Journal of Child Psychology and Psychiatry, 56(6), 632–639. 10.1111/jcpp.12337 - DOI - PMC - PubMed
    1. Kok F. M., Groen Y., Fuermaier A. B. & Tucha O. (2016). Problematic peer functioning in girls with ADHD: A systematic literature review. PloS one, 11(11), e0165119 10.1371/journal.pone.0165119 - DOI - PMC - PubMed
    1. Monuteaux M. C., Mick E., Faraone S. V., & Biederman J. (2010). The influence of sex on the course and psychiatric correlates of ADHD from childhood to adolescence: A longitudinal study. Journal of Child Psychology and Psychiatry, 51(3), 233–241. 10.1111/j.1469-7610.2009.02152.x - DOI - PMC - PubMed
    1. Robison R. J., Reimherr F. W., Marchant B. K., Faraone S. V., Adler L. A. & West S. A. (2008). Gender differences in 2 clinical trials of adults with attentiondeficit/hyperactivity disorder: A retrospective data analysis. Journal of Clinical Psychiatry, 69(2), 213–221. 10.4088/jcp.v69n0207 - DOI - PubMed

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