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doi: 10.1016/j.chembiol.2020.08.003.
For Wnt Signaling, Fucosylation of LRP6 Is a Bitter Pill
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- PMID: 32946757
- DOI: 10.1016/j.chembiol.2020.08.003
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For Wnt Signaling, Fucosylation of LRP6 Is a Bitter Pill
Cell Chem Biol.
.
Free article
Abstract
In this issue of Cell Chemical Biology, Hong et al. (2020) use in situ chemoenzymatic labeling to discover that fucosylation of the Wnt co-receptor LRP6 induces its endocytosis and downregulates Wnt/β-catenin signaling. Their findings reveal a glycosylation-based mechanism for regulating Wnt signaling that could be targeted in cancer.
Copyright © 2020 Elsevier Ltd. All rights reserved.
Comment on
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In Situ Fucosylation of the Wnt Co-receptor LRP6 Increases Its Endocytosis and Reduces Wnt/β-Catenin Signaling.Cell Chem Biol. 2020 Sep 17;27(9):1140-1150.e4. doi: 10.1016/j.chembiol.2020.06.015. Epub 2020 Jul 9. Cell Chem Biol. 2020. PMID: 32649905 Free PMC article.
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