Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Sep 17;27(9):1114-1116.
doi: 10.1016/j.chembiol.2020.08.003.

For Wnt Signaling, Fucosylation of LRP6 Is a Bitter Pill

Adnan Shami Shah  1 , Hongyan Sun  1 , Jeremy M Baskin  2
Affiliations
Free article
Comment

For Wnt Signaling, Fucosylation of LRP6 Is a Bitter Pill

Adnan Shami Shah et al. Cell Chem Biol. .
Free article

Abstract

In this issue of Cell Chemical Biology, Hong et al. (2020) use in situ chemoenzymatic labeling to discover that fucosylation of the Wnt co-receptor LRP6 induces its endocytosis and downregulates Wnt/β-catenin signaling. Their findings reveal a glycosylation-based mechanism for regulating Wnt signaling that could be targeted in cancer.

PubMed Disclaimer

Comment on

Publication types

MeSH terms

Substances

LinkOut - more resources