The Mind of a Mouse

Larry F Abbott¹, Davi D Bock², Edward M Callaway³, Winfried Denk⁴, Catherine Dulac⁵, Adrienne L Fairhall⁶, Ila Fiete⁷, Kristen M Harris⁸, Moritz Helmstaedter⁹, Viren Jain¹⁰, Narayanan Kasthuri¹¹, Yann LeCun¹², Jeff W Lichtman¹³, Peter B Littlewood¹⁴, Liqun Luo¹⁵, John H R Maunsell¹⁶, R Clay Reid¹⁷, Bruce R Rosen¹⁸, Gerald M Rubin¹⁹, Terrence J Sejnowski²⁰, H Sebastian Seung²¹, Karel Svoboda¹⁹, David W Tank²², Doris Tsao²³, David C Van Essen²⁴

Affiliations

¹ Zuckerman Mind, Brain and Behavior Institute, Department of Neuroscience, Department of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.
² Larner College of Medicine, University of Vermont, Burlington, VT, USA.
³ Salk Institute for Biological Studies, La Jolla, CA, USA.
⁴ Max Planck Institute of Neurobiology, Martinsried, Germany.
⁵ Howard Hughes Medical Institute and Department of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA, USA.
⁶ Department of Physiology and Biophysics and Computational Neuroscience Center, University of Washington, Seattle, WA, USA.
⁷ Department of Brain and Cognitive Sciences and McGovern Institute, MIT, Cambridge, MA, USA.
⁸ Center for Learning and Memory, Institute for Neuroscience, University of Texas - Austin, Austin, TX, USA.
⁹ Department of Connectomics, Max Planck Institute for Brain Research, Frankfurt, Germany.
¹⁰ Google Research, Mountain View, CA, USA. Electronic address: viren@google.com.
¹¹ Argonne National Laboratory and Department of Neurobiology, University of Chicago, Chicago, IL, USA.
¹² Courant Institute, Center for Data Science and Center for Neural Science, New York University and Facebook AI Research, New York, NY, USA.
¹³ Center for Brain Science and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA. Electronic address: jeff@mcb.harvard.edu.
¹⁴ Department of Physics and James Franck Institute, University of Chicago, Chicago, IL, USA.
¹⁵ Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA, USA.
¹⁶ Department of Neurobiology and Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, University of Chicago, Chicago, IL, USA.
¹⁷ Allen Institute for Brain Science, Seattle, WA, USA.
¹⁸ Athinoula A. Martinos Center for Biomedical Imaging and Department of Radiology, Harvard Medical School, Boston, MA, USA.
¹⁹ Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
²⁰ Salk Institute for Biological Studies, La Jolla, CA, USA; Division of Biological Sciences, University of California, San Diego, San Diego, CA, USA.
²¹ Department of Computer Science and Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
²² Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
²³ Division of Biology and Biological Engineering, Tianqiao and Chrissy Chen Institute for Neuroscience and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA, USA.
²⁴ Neuroscience Department, Washington University School of Medicine, St. Louis, MO, USA.

PMID: 32946777
DOI: 10.1016/j.cell.2020.08.010

Free article

The Mind of a Mouse

Larry F Abbott et al. Cell. 2020.

Free article

. 2020 Sep 17;182(6):1372-1376.

doi: 10.1016/j.cell.2020.08.010.

Authors

Affiliations

¹ Zuckerman Mind, Brain and Behavior Institute, Department of Neuroscience, Department of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.
² Larner College of Medicine, University of Vermont, Burlington, VT, USA.
³ Salk Institute for Biological Studies, La Jolla, CA, USA.
⁴ Max Planck Institute of Neurobiology, Martinsried, Germany.
⁵ Howard Hughes Medical Institute and Department of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA, USA.
⁶ Department of Physiology and Biophysics and Computational Neuroscience Center, University of Washington, Seattle, WA, USA.
⁷ Department of Brain and Cognitive Sciences and McGovern Institute, MIT, Cambridge, MA, USA.
⁸ Center for Learning and Memory, Institute for Neuroscience, University of Texas - Austin, Austin, TX, USA.
⁹ Department of Connectomics, Max Planck Institute for Brain Research, Frankfurt, Germany.
¹⁰ Google Research, Mountain View, CA, USA. Electronic address: viren@google.com.
¹¹ Argonne National Laboratory and Department of Neurobiology, University of Chicago, Chicago, IL, USA.
¹² Courant Institute, Center for Data Science and Center for Neural Science, New York University and Facebook AI Research, New York, NY, USA.
¹³ Center for Brain Science and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA. Electronic address: jeff@mcb.harvard.edu.
¹⁴ Department of Physics and James Franck Institute, University of Chicago, Chicago, IL, USA.
¹⁵ Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA, USA.
¹⁶ Department of Neurobiology and Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, University of Chicago, Chicago, IL, USA.
¹⁷ Allen Institute for Brain Science, Seattle, WA, USA.
¹⁸ Athinoula A. Martinos Center for Biomedical Imaging and Department of Radiology, Harvard Medical School, Boston, MA, USA.
¹⁹ Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
²⁰ Salk Institute for Biological Studies, La Jolla, CA, USA; Division of Biological Sciences, University of California, San Diego, San Diego, CA, USA.
²¹ Department of Computer Science and Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
²² Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
²³ Division of Biology and Biological Engineering, Tianqiao and Chrissy Chen Institute for Neuroscience and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA, USA.
²⁴ Neuroscience Department, Washington University School of Medicine, St. Louis, MO, USA.

PMID: 32946777
DOI: 10.1016/j.cell.2020.08.010

Abstract

Large scientific projects in genomics and astronomy are influential not because they answer any single question but because they enable investigation of continuously arising new questions from the same data-rich sources. Advances in automated mapping of the brain's synaptic connections (connectomics) suggest that the complicated circuits underlying brain function are ripe for analysis. We discuss benefits of mapping a mouse brain at the level of synapses.

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The Mind of a Mouse

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The Mind of a Mouse

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