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. 2021 Jul 3;13(4):327-333.
doi: 10.1093/inthealth/ihaa059.

Prevalence of cystic echinococcosis and associated risk factors among humans in Khartoum State, Central Sudan

Mohamed E Ahmed  1   2   3 , Sara Siddig Abdalla  1   3   4 , Ibrahim A Adam  3 , Martin P Grobusch  5 , Imadeldin E Aradaib  1   3
Affiliations

Prevalence of cystic echinococcosis and associated risk factors among humans in Khartoum State, Central Sudan

Mohamed E Ahmed et al. Int Health. .

Abstract

Background: Hydatid disease or cystic echinococcosis (CE) is caused by the larval stages of the cestode parasite Echinococcus granulosus. The objectives of this study were to estimate the prevalence of seropositivity and to identify the risk factors associated with the disease among humans in Khartoum State, Central Sudan.

Methods: A cross-sectional study was conducted between November 2017 and April 2018. A total of 305 randomly selected consenting participants from three localities were included in the current investigation using a multistage probability sampling method. An in-house enzyme-linked immunosorbent assay was used to detect immunoglobulin G antibodies to E. granulosus. The χ2 test and logistic regression analysis were used to determine the risk factors associated with CE seropositivity.

Results: A seroprevalence of 6.5% (20/305) was recorded among humans in Khartoum State, Central Sudan. Age (odds ratio [OR] 16.61 [confidence interval {CI} 2.21 to 117.92], p=0.006), locality (OR 3.08 [CI 1.42 to 22.54], p=0.011) and contact with dogs (OR 2.34 [CI 0.026 to 0.646], p=0.013) were recorded as potential risk factors for seropositivity to CE in the study area.

Conclusions: The seroprevalence of CE (6.5%) is high among humans in Khartoum State, Central Sudan. Improved surveillance is necessary to optimize control and prevention strategies for CE as an important neglected zoonotic disease among the human population in the study area of Central Sudan.

Keywords: ELISA; Echinococcus granulosus; Sudan; epidemiology; hydatid disease; survey.

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References

    1. Ahmed ME, Eltom KH, Musa NOet al. First report on circulation of Echinococcus ortleppi in the one humped camel (Camelus dromedaries), Sudan. BMC Vet Res. 2013;9:127. - PMC - PubMed
    1. Omer RA, Dinkle A, Romig Tet al. A molecular survey of cystic echinococcosis in Sudan. Vet Parasitol. 2010;169(3–4):340–6. - PubMed
    1. Craig PS, McManus DP, Lightowlers MWet al. Prevention and control of cystic echinococcosis. Lancet Infect Dis. 2007;7(6):385–94. - PubMed
    1. Battelli G, Mantovani A, Seimenis A. Cystic echinococcosis and the Mediterranean Region: a long-lasting association. Parassitologia. 2007;44(1–2):43–57. - PubMed
    1. Eckert J, Deplazes P. Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern. Clin Microbiol Rev. 2004;17(1):107–35. - PMC - PubMed