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. 2021 Feb;51(2):483-486.
doi: 10.1002/eji.202048665. Epub 2020 Oct 14.

White matter lesions in multiple sclerosis are enriched for CD20dim CD8+ tissue-resident memory T cells

Cheng-Chih Hsiao  1   2 , Nina L Fransen  1 , Aletta M R van den Bosch  1 , Kim I M Brandwijk  3 , Inge Huitinga  1   4 , Jörg Hamann  1   2 , Joost Smolders  1   5
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Free article

White matter lesions in multiple sclerosis are enriched for CD20dim CD8+ tissue-resident memory T cells

Cheng-Chih Hsiao et al. Eur J Immunol. 2021 Feb.
Free article

Abstract

Brain CD8+ CD69+ tissue-resident memory T (TRM ) cells comprise a CD20dim subset, which is proportionally larger in CD103-negative TRM cells. In multiple sclerosis (MS) lesions, CD20dim TRM -cell proportions are increased. CD20-expression is associated with higher levels of CXCR6, Ki-67, and granzyme B, supporting CD20dim TRM cells as a relevant subset in MS.

Keywords: CD20; brain; human; multiple sclerosis; tissue-resident memory T cells.

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