Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 May-Jun;17(5):1479164120953626.
doi: 10.1177/1479164120953626.

Relation of Helicobacter pylori infection to peripheral arterial stiffness and 10-year cardiovascular risk in subjects with diabetes mellitus

Yun-Feng Yang  1 , Yun Li  1 , Ju-Hua Liu  1   2 , Xiao-Ming Wang  1 , Bi-Hua Wu  1 , Cheng-Shi He  2 , Jian-Wei Gu  1
Affiliations

Relation of Helicobacter pylori infection to peripheral arterial stiffness and 10-year cardiovascular risk in subjects with diabetes mellitus

Yun-Feng Yang et al. Diab Vasc Dis Res. 2020 May-Jun.

Abstract

Purpose: This study was conducted to investigate the relation of HP infection to peripheral arterial stiffness and 10-year cardiovascular risk in diabetes mellitus (DM).

Methods: DM subjects who underwent the C13-breath test were enrolled and divided into DMHP+ and DMHP- groups. Peripheral arterial stiffness was measured using brachial to ankle pulse wave velocity (baPWV). Framingham score (FRS) and Chinese evaluation method of ischemic cardiovascular diseases (ICVD) were used to clarify 10-year cardiovascular risk.

Results: A total of 6767 subjects were included, baPWV and proportion of subjects with severe peripheral arterial stiffness were lower in DMHP- group than DMHP+ group (1556.68 ± 227.54 vs 2031.61 ± 525.48 cm/s, p < 0.01; 21.9% vs 62.7%, p < 0.01). Multivariate logistic regression analysis demonstrated that HP infection was independently associated with baPWV. Furthermore, cardiovascular risk score and the proportion of subjects with high risk were lower in DMHP- group than DMHP+ group (FRS: 12.09 ± 3.77 vs 13.91 ± 3.77, 17.2% vs 38.8%; ICVD: 8.56 ± 2.99 vs 10.22 ± 3.16, 43.9% vs 65.4%, with all p < 0.05).

Conclusion: DM subjects with HP infection had more severe peripheral arterial stiffness compared those without HP infection, a higher cardiovascular risk score and 10-year cardiovascular risk stratification were observed in those subjects.

Keywords: Chinese ICVD; Diabetes mellitus; Framingham score; Helicobacter pylori; peripheral arterial stiffness.

PubMed Disclaimer

Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Percentage of different stage of arterial stiffness distribution in subjects with DM with and without HP infection.
Figure 2.
Figure 2.
Percentage of different cardiovascular disease risk stratification in subjects with DM with and without HP infection.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Balakumar P, Maung-UK, Jagadeesh G. Prevalence and prevention of cardiovascular disease and diabetes mellitus. Pharmacol Res 2016; 113: 600–609. - PubMed
    1. Newman JD, Schwartzbard AZ, Weintraub HS, et al.. Primary prevention of cardiovascular disease in diabetes mellitus. J Am Coll Cardiol 2017; 70(7): 883–893. - PMC - PubMed
    1. Hosseininasab Nodoushan SA, Nabavi A. The interaction of Helicobacter pylori infection and type 2 diabetes mellitus. Adv Biomed Res 2019; 8: 15. - PMC - PubMed
    1. Wan Z, Hu L, Hu M, et al.. Helicobacter pylori infection and prevalence of high blood pressure among Chinese adults. J Hum Hypertens 2018; 32(2): 158–164. - PubMed
    1. Choi JM, Lim SH, Han YM, et al.. Association between Helicobacter pylori infection and arterial stiffness: results from a large cross-sectional study. PLoS ONE 2019; 14(8): e0221643. - PMC - PubMed

Publication types

MeSH terms