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. 2020 May-Jun;17(5):1479164120953626.
doi: 10.1177/1479164120953626.

Relation of Helicobacter pylori infection to peripheral arterial stiffness and 10-year cardiovascular risk in subjects with diabetes mellitus

Yun-Feng Yang  1 , Yun Li  1 , Ju-Hua Liu  1   2 , Xiao-Ming Wang  1 , Bi-Hua Wu  1 , Cheng-Shi He  2 , Jian-Wei Gu  1
Affiliations

Relation of Helicobacter pylori infection to peripheral arterial stiffness and 10-year cardiovascular risk in subjects with diabetes mellitus

Yun-Feng Yang et al. Diab Vasc Dis Res. 2020 May-Jun.

Abstract

Purpose: This study was conducted to investigate the relation of HP infection to peripheral arterial stiffness and 10-year cardiovascular risk in diabetes mellitus (DM).

Methods: DM subjects who underwent the C13-breath test were enrolled and divided into DMHP+ and DMHP- groups. Peripheral arterial stiffness was measured using brachial to ankle pulse wave velocity (baPWV). Framingham score (FRS) and Chinese evaluation method of ischemic cardiovascular diseases (ICVD) were used to clarify 10-year cardiovascular risk.

Results: A total of 6767 subjects were included, baPWV and proportion of subjects with severe peripheral arterial stiffness were lower in DMHP- group than DMHP+ group (1556.68 ± 227.54 vs 2031.61 ± 525.48 cm/s, p < 0.01; 21.9% vs 62.7%, p < 0.01). Multivariate logistic regression analysis demonstrated that HP infection was independently associated with baPWV. Furthermore, cardiovascular risk score and the proportion of subjects with high risk were lower in DMHP- group than DMHP+ group (FRS: 12.09 ± 3.77 vs 13.91 ± 3.77, 17.2% vs 38.8%; ICVD: 8.56 ± 2.99 vs 10.22 ± 3.16, 43.9% vs 65.4%, with all p < 0.05).

Conclusion: DM subjects with HP infection had more severe peripheral arterial stiffness compared those without HP infection, a higher cardiovascular risk score and 10-year cardiovascular risk stratification were observed in those subjects.

Keywords: Chinese ICVD; Diabetes mellitus; Framingham score; Helicobacter pylori; peripheral arterial stiffness.

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Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Percentage of different stage of arterial stiffness distribution in subjects with DM with and without HP infection.
Figure 2.
Figure 2.
Percentage of different cardiovascular disease risk stratification in subjects with DM with and without HP infection.
See this image and copyright information in PMC

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