Epidemiological aspects and spatial patterns of human visceral leishmaniasis in Brazil

doi:10.1017/S0031182020001754

. 2020 Dec;147(14):1665-1677.

doi: 10.1017/S0031182020001754. Epub 2020 Sep 21.

Epidemiological aspects and spatial patterns of human visceral leishmaniasis in Brazil

Iolanda Graepp-Fontoura^{1

2}, David Soeiro Barbosa³, Luiz Fernando Costa Nascimento^{4

5}, Volmar Morais Fontoura⁶, Adriana Gomes Nogueira Ferreira^{2

7}, Francisca Aline Arrais Sampaio Santos², Benedito Salazar Sousa⁸, Floriacy Stabnow Santos^{2

7}, Marcelino Santos-Neto^{2

7}, Leonardo Hunaldo Dos Santos^{2

7}, Ana Lúcia Abreu-Silva^{1

9}

Affiliations

¹ Graduate Program in Health Sciences, Universidade Federal do Maranhão, Avenue of Portuguese 1966, 65080-805, Bacanga, São Luís, Maranhão, Brazil.
² Department of Nursing, Universidade Federal do Maranhão, Avenue da Universidade, Dom Afonso Felipe Gregory, 65.915-240, Imperatriz, Maranhão, Brazil.
³ Department of Parasitology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Avenue Presidente Antônio Carlos 6627, 31275-035, Belo Horizonte, Minas Gerais, Brazil.
⁴ Postgraduate Program on Mechanical Engineering, Department of Energy, Universidade Estadual de São Paulo, Avenue Ariberto Pereira da Cunha, 333, 12516-410, Guaratinguetá, São Paulo, Brazil.
⁵ Department of Environmental Sciences, Universidade de Taubaté, Dr. José Luiz Cembranelli, 5000, Taubaté, São Paulo, 12081-010, Itaim District, Brazil.
⁶ Department of Nursing, Universidade Estadual do Tocantins, Pedro Ludovico, 535, Boa Vista, 77960-000, Augustinópolis, Tocantins, Brazil.
⁷ Master Course in Health and Technology (PPGST-UFMA), Avenue da Universidade, Dom Afonso Felipe Gregory, 65.915-240, Imperatriz (MA), Brazil.
⁸ Instituto de Ensino Superior do Maranhão - IESMA/UNISULMA, São Pedro, 11, Jardim Cristo Rei, 65907-070, Imperatriz, Maranhão, Brazil.
⁹ Department of Pathology, Universidade Estadual do Maranhão, Cross Paulo VI, 65080-805, Cidade Universitária, São Luís, Maranhão, Brazil.

PMID: 32951622
PMCID: PMC10317731
DOI: 10.1017/S0031182020001754

Epidemiological aspects and spatial patterns of human visceral leishmaniasis in Brazil

Iolanda Graepp-Fontoura et al. Parasitology. 2020 Dec.

. 2020 Dec;147(14):1665-1677.

doi: 10.1017/S0031182020001754. Epub 2020 Sep 21.

Authors

Affiliations

¹ Graduate Program in Health Sciences, Universidade Federal do Maranhão, Avenue of Portuguese 1966, 65080-805, Bacanga, São Luís, Maranhão, Brazil.
² Department of Nursing, Universidade Federal do Maranhão, Avenue da Universidade, Dom Afonso Felipe Gregory, 65.915-240, Imperatriz, Maranhão, Brazil.
³ Department of Parasitology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Avenue Presidente Antônio Carlos 6627, 31275-035, Belo Horizonte, Minas Gerais, Brazil.
⁴ Postgraduate Program on Mechanical Engineering, Department of Energy, Universidade Estadual de São Paulo, Avenue Ariberto Pereira da Cunha, 333, 12516-410, Guaratinguetá, São Paulo, Brazil.
⁵ Department of Environmental Sciences, Universidade de Taubaté, Dr. José Luiz Cembranelli, 5000, Taubaté, São Paulo, 12081-010, Itaim District, Brazil.
⁶ Department of Nursing, Universidade Estadual do Tocantins, Pedro Ludovico, 535, Boa Vista, 77960-000, Augustinópolis, Tocantins, Brazil.
⁷ Master Course in Health and Technology (PPGST-UFMA), Avenue da Universidade, Dom Afonso Felipe Gregory, 65.915-240, Imperatriz (MA), Brazil.
⁸ Instituto de Ensino Superior do Maranhão - IESMA/UNISULMA, São Pedro, 11, Jardim Cristo Rei, 65907-070, Imperatriz, Maranhão, Brazil.
⁹ Department of Pathology, Universidade Estadual do Maranhão, Cross Paulo VI, 65080-805, Cidade Universitária, São Luís, Maranhão, Brazil.

PMID: 32951622
PMCID: PMC10317731
DOI: 10.1017/S0031182020001754

Abstract

Human visceral leishmaniasis (HVL) cases are important public health problems due to their zoonotic aspect, with high rates of morbidity and mortality in Brazil. The aim of this this study was to identify spatial patterns in both rates of HVL cases in Brazilian states during the period from 2006 to 2015. This is an ecological study, using geoprocessing tools to create choropleth maps, based on secondary data from open access platforms, to identify priority areas for control actions of the disease. Data were collected in 2017 and analysed according to the global and local Moran's I, using TerraView 4.2.2 software. Similar clusters were observed in neighbouring municipalities in thematic maps of HVL, suggesting spatial similarity in the distribution of the disease in humans mainly in the North and Northeast Regions, which concentrate the states with the highest rates of HVL. Heterogeneous spatial patterns were observed in the distribution of HVL, which show municipalities that need higher priority in the intensification of disease surveillance and control strategies.

Keywords: Brazil; human visceral leishmaniasis; leishmaniasis; spatial analysis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Fig. 1.**
HVL data by municipalities of residence in Brazil, between the years 2006 to 2015. (A) Crude rate distribution per 100 000 inhabitants; (B) Moran map; (C) LISA map.

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References

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[1] Albuquerque LCPD, Mendonça IR, Cardoso PN, Baldaçara LR, Borges MRMM, da Borges JC and da Pranchevicius MCS (2014) HIV/AIDS-related visceral leishmaniasis: a clinical and epidemiological description of visceral leishmaniasis in northern Brazil. Revista da Sociedade Brasileira de Medicina Tropical 47, 38–46. - PubMed

[2] Albuquerque LCPD, Mendonça IR, Cardoso PN, Baldaçara LR, Borges MRMM, da Borges JC and da Pranchevicius MCS (2014) HIV/AIDS-related visceral leishmaniasis: a clinical and epidemiological description of visceral leishmaniasis in northern Brazil. Revista da Sociedade Brasileira de Medicina Tropical 47, 38–46. - PubMed

[3] Alexandrino-de-Oliveira P, Santos-Oliveira JR, Dorval MEC, das Da-Costa FCB, Pereira GROL, da Cunha RV, Paniago AMM and Da-Cruz AM (2010) HIV/AIDS-associated visceral leishmaniasis in patients from an endemic area in Central-west Brazil. Memórias do Instituto Oswaldo Cruz 105, 692–697. - PubMed

[4] Alexandrino-de-Oliveira P, Santos-Oliveira JR, Dorval MEC, das Da-Costa FCB, Pereira GROL, da Cunha RV, Paniago AMM and Da-Cruz AM (2010) HIV/AIDS-associated visceral leishmaniasis in patients from an endemic area in Central-west Brazil. Memórias do Instituto Oswaldo Cruz 105, 692–697. - PubMed

[5] Araújo VEM, Morais MHF, Reis IA, Rabello A and Carneiro M (2012) Early clinical manifestations associated with death from visceral leishmaniasis. PLoS Neglected Tropical Diseases 6, e1511. - PMC - PubMed

[6] Araújo VEM, Morais MHF, Reis IA, Rabello A and Carneiro M (2012) Early clinical manifestations associated with death from visceral leishmaniasis. PLoS Neglected Tropical Diseases 6, e1511. - PMC - PubMed

[7] Araújo VEM, Pinheiro LC, de Almeida MCM, de Menezes FC, Morais MHF, Reis IA, Assunção RM and Carneiro M (2013) Relative risk of visceral leishmaniasis in Brazil: a spatial analysis in urban area. PLoS Neglected Tropical Diseases 7, e2540. - PMC - PubMed

[8] Araújo VEM, Pinheiro LC, de Almeida MCM, de Menezes FC, Morais MHF, Reis IA, Assunção RM and Carneiro M (2013) Relative risk of visceral leishmaniasis in Brazil: a spatial analysis in urban area. PLoS Neglected Tropical Diseases 7, e2540. - PMC - PubMed

[9] Arruda RMF, Cardoso DT, Teixeira-Neto RG, Barbosa DS, Ferraz RK, Morais MHF, Belo VS and da Silva ES (2019) Space-time analysis of the incidence of human visceral leishmaniasis (VL) and prevalence of canine VL in a municipality of southeastern Brazil: identification of priority areas for surveillance and control. Acta Tropica 197, 105052. - PubMed

[10] Arruda RMF, Cardoso DT, Teixeira-Neto RG, Barbosa DS, Ferraz RK, Morais MHF, Belo VS and da Silva ES (2019) Space-time analysis of the incidence of human visceral leishmaniasis (VL) and prevalence of canine VL in a municipality of southeastern Brazil: identification of priority areas for surveillance and control. Acta Tropica 197, 105052. - PubMed

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Epidemiological aspects and spatial patterns of human visceral leishmaniasis in Brazil

Affiliations

Epidemiological aspects and spatial patterns of human visceral leishmaniasis in Brazil

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

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References

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LinkOut - more resources

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