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Comment
. 2020 Dec;36(12):899-901.
doi: 10.1016/j.tig.2020.09.001. Epub 2020 Sep 18.

Base Editing Landscape Extends to Perform Transversion Mutation

Kutubuddin A Molla  1 , Yiping Qi  2 , Subhasis Karmakar  3 , Mirza J Baig  3
Affiliations
Comment

Base Editing Landscape Extends to Perform Transversion Mutation

Kutubuddin A Molla et al. Trends Genet. 2020 Dec.

Abstract

Base editors have drawn considerable academic and industrial attention in recent years because of their ability to alter single DNA bases with precision. However, the existing cytosine and adenine base editors can only install transition mutations. Three recent studies (Kurt et al.,Zhao et al., and Chen et al.) expand the base editing toolbox by developing cytosine transversion base editors.

Keywords: C-to-G editing; CRISPR/Cas; agriculture; base editing; point mutation; therapeutics; transversion base editor.

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