Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep 16:44:e116.
doi: 10.26633/RPSP.2020.116. eCollection 2020.

Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon

Consuelo S de Oliveira  1 , Haroldo José de Matos  1 , Francisco Luzio de Paula Ramos  1 , Ana Yece das N Pinto  1 , Priscila Nathyelly Dos S Graim  2 , Vivianne de Paula R Guimarães  2 , Luna Thaís S Gomes  1 , Emilene M F Serra  1 , Ana Cecília Cruz  1 , Alessandra Leal  1 , Daniele F Henriques  1 , Juliana A Lima  1 , Maura V Anjos  1 , Eliana V Pinto  1 , Alana W de Souza  1 , Pedro Fernando da C Vasconcelos  1
Affiliations

Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon

Consuelo S de Oliveira et al. Rev Panam Salud Publica. .

Abstract
in English, Spanish

Objective: To establish the risk of microcephaly in neonates born to women infected with ZIKV during pregnancy.

Methods: A cohort of laboratory-confirmed ZIKV cases of congenital infections (109 mothers infected during pregnancy and 101 newborns) among 308 suspect cases was followed in Belem, Pará, Brazil, from October 2015 to December 2017.

Results: A microcephaly risk of 1.98% (95% CI 0.54-6.93%) was found, or 2 cases among the 101 neonates infected with ZIKV during pregnancy. 72% of the pregnant women had ZIKV infection confirmed by RT-qPCR during gestation.

Conclusions: Results showed a low incidence of ZIKV-associated birth defects, stillbirth, and miscarriage, which contrasts with previous studies in other Brazilian regions. Previous exposure to yellow fever vaccine and/or multiserotype DENV infection could be implicated in the protection from ZIKV congenital infection.

Objetivo: Establecer el riesgo de microcefalia en los recién nacidos de mujeres infectadas con ZIKV durante el embarazo.

Métodos: Se siguió a una cohorte de casos con infección congénita por ZIKV confirmada por laboratorio (109 madres infectadas durante el embarazo, 101 recién nacidos) conformada a partir de 308 casos sospechosos en Belem, Pará, Brasil, de octubre de 2015 a diciembre de 2017.

Resultados: Se encontró un riesgo de microcefalia de 1,98% (IC95% 0,54-6,93%), o 2 casos entre los 101 neonatos infectados con ZIKV durante el embarazo. En el 72% de las mujeres embarazadas se confirmó mediante RT-qPCR la infección por ZIKV durante la gestación.

Conclusiones: Los resultados mostraron una baja incidencia de malformaciones congénitas, mortinatos y abortos asociados al ZIKV, lo que contrasta con estudios anteriores de otras regiones de Brasil. La exposición previa a la vacuna contra la fiebre amarilla o la infección previa por varios serotipos de virus del dengue podrían estar implicados en la protección contra la infección congénita por ZIKV.

Keywords: Brazil; Zika virus infection; infectious; microcephaly; pregnancy complications.

PubMed Disclaimer

Figures

FIGURA 1.
FIGURA 1.. Temporal distribution of ZIKV pregnant women suspected cases, October 2015 to December 2016.
FIGURA 2.
FIGURA 2.. Study population of the 109 pregnant women with laboratory-confirmed ZIKV recent infection who were followed-up
See this image and copyright information in PMC

References

    1. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde Vírus Zika no Brasil: a resposta do SUS . Brasília: Ministério da Saúde; 2017. Ministério da Saúde, Secretaria de Vigilância em Saúde; pp. p 81–88.
    2. 1. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde Vírus Zika no Brasil: a resposta do SUS. Ministério da Saúde, Secretaria de Vigilância em Saúde. – Brasília: Ministério da Saúde; 2017. p 81-88.
    1. Reynolds MR, Jones AM, Petersen EE, et al. Vital signs: update on Zika virus–associated birth defects and evaluation of all U.S. infants with congenital Zika virus exposure — U.S. Zika Pregnancy Registry, 2016. MMWR Morb Mortal Wkly Rep. 2017;66:366–373. - PMC - PubMed
    2. 2. Reynolds MR, Jones AM, Petersen EE, et al. Vital signs: update on Zika virus–associated birth defects and evaluation of all U.S. infants with congenital Zika virus exposure — U.S. Zika Pregnancy Registry, 2016. MMWR Morb Mortal Wkly Rep. 2017; 66: 366-73. - PMC - PubMed
    1. Jaenish T, Rosenberger KD, Brito C, Brady O, Brasil P, Marques ET. Risk of microcephaly after Zika vírus infection in Brazil, 2015 t0 2016. Bull World Health Organ. 2017;95(3):191–198. - PMC - PubMed
    2. 3. Jaenish T; Rosenberger KD; Brito C; Brady O; Brasil P; Marques ET. Risk of microcephaly after Zika vírus infection in Brazil, 2015 t0 2016. Bull World Health Organ. 2017;95(3):191-198. - PMC - PubMed
    1. Cauchemez S, Besnard M, Bonpard P, Dub T, Guillemette-Artur, Eyro lle-Guignot D, et al. Association between Zika virus and microcephaly in French Polynesia, 2013–2015: a retrospective study. Lancet. 2016;87(10033):2125–2132. - PMC - PubMed
    2. 4. Cauchemez S, Besnard M, Bonpard P, Dub T, Guillemette-Artur, Eyro lle-Guignot D, et al. Association between Zika virus and microcephaly in French Polynesia, 2013–2015: a retrospective study. Lancet. 2016;87(10033): 2125–2132. - PMC - PubMed
    1. Sharp TM, Fischer M, Muñoz-Jordán JL, et al. Dengue and Zika Virus Diagnostic Testing for Patients with a Clinically Compatible Illness and Risk for Infection with Both Viruses. MMWR Recomm Rep. 2019;68(No. RR-1):1–10. doi: 10.15585/mmwr.rr6801a1externalicon. - DOI - PMC - PubMed
    2. 5. Sharp TM, Fischer M, Muñoz-Jordán JL, et al. Dengue and Zika Virus Diagnostic Testing for Patients with a Clinically Compatible Illness and Risk for Infection with Both Viruses. MMWR Recomm Rep. 2019;68(No. RR-1):1–10. DOI: http://dx.doi.org/10.15585/mmwr.rr6801a1external icon. - PMC - PubMed

LinkOut - more resources