Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jul 14:36:185.
doi: 10.11604/pamj.2020.36.185.22128. eCollection 2020.

Dengue virus serological markers among potential blood donors: an evidence of asymptomatic dengue virus transmission in Cameroon

Salomon Bonsi Tchuandom  1   2 , Abel Lissom  3   4 , Ghislaine Haverie Mimfoumou Ateba  5 , Thibau Flaurant Tchouangueu  1   3 , Constantin Tchakounte  1 , Agbor Rolland Ayuk  6 , Etienne Philemon Atabonkeng  1 , Ankiambom Innocent Ngong  2   4 , Godwin Nchinda  3 , Jules-Roger Kuiate  1
Affiliations

Dengue virus serological markers among potential blood donors: an evidence of asymptomatic dengue virus transmission in Cameroon

Salomon Bonsi Tchuandom et al. Pan Afr Med J. .

Abstract

Introduction: the risk of dengue virus or its antibodies which can be transmitted through blood transfusion by asymptomatic individuals infected, has been a major concern all over the world. Dengue is an endemic disease in sub-Saharan Africa, particularly in Cameroon. The purpose of this study is to determine the frequency of dengue virus (DENV) infection among potential blood donors at Yaounde Jamot Hospital.

Methods: serum samples were collected from 310 potential adult blood donors aged 18-57 years, who signed a written informed consent and completed the questionnaire between March 2019 and August 2019. This serum is used to screen for the presence of serological markers of DENV infection (NS1, IgM and IgG) using immunochromatographic tests (Zhuhai Encode Medical Engineering Co., Ltd, China). IgM/IgG positive samples were confirmed by enzyme-linked immunosorbent assays (ELISA).

Results: the overall prevalence was 24.8% among potential blood donors were subdivided as follows: 4.5% (14/310), 12.3% (38/310) and 6.1% (19/310) showed mono-positivity to DENV-NS1 antigen, anti-DENV IgM and anti-DENV IgG antibodies respectively. 1.9% (6/310) of potential blood donors showed dual positivity to anti-DENV IgM antibodies and anti-DENV IgG antibodies. The presence of DENV-NS1 antigen show asymptomatic viremia of dengue at the time of donation, while the presence of IgG antibodies reflects the high endemicity of dengue disease in the city of Yaoundé.

Conclusion: these findings demonstrate the high level of risk of the DENV transmission among potential blood donors to needy recipients, underscoring the importance of establishing dengue fever blood screening in different services and blood collection units in Cameroon to improve safety transfusion and control the dissemination of the DENV.

Keywords: Cameroon; Dengue fever; potential blood donors; seroprevalence.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
distribution of donors with respect to the serological markers of dengue virus
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Brady OJ, Gething PW, Bhatt S, Messina JP, Brownstein JS, Hoen AG, et al. Refining the global spatial limits of dengue virus transmission by evidence-based consensus. PLoS Neglected Tropical Diseases. 2012;6(8):e1760. - PMC - PubMed
    1. Karim F, Nasir N, Moiz B. Transfusion transmitted dengue: one donor infects two patients. Transfus Apher Sci. 2017 Apr;56(2):151–3. - PubMed
    1. Mangwana S. Dengue viremia in blood donors in Northern India: challenges of emerging dengue outbreaks to blood transfusion safety. Asian J Transfus Sci. 2015 Jul-Dec;9(2):177–80. - PMC - PubMed
    1. Pozzetto B, Garraud O. Risques viraux émergents en transfusion sanguine. Transfusion Clinique et Biologique. 2011;18(2):174–83. - PMC - PubMed
    1. Pozzetto B, Memmi M, Garraud O. Is transfusion-transmitted dengue fever a potential public health threat. World Journal of Virology. 2015 May 12;4(2):113–23. - PMC - PubMed

MeSH terms